Biomedical subjects

V A Fadeev

Publications and source records attributed to V A Fadeev.

7 recordsLinked to original sources

PubMed1986

[Effect of erythrocytes isolated from the blood of animals with experimental tumors on the proliferative activity of cultured tumor cells].

It has been established that erythrocytes taken from blood of mice with experimental tumors being in the active phase of growth, or of mice with a recidivation of the primary tumor intensify proliferative processes in the culture of tumor cells. Erythrocytes from animals with tumors being in the stationary phase of growth did not reveal such a capacity. The authors connect such an effect with the erythrocyte transport function due to which they can store up those factors excreted by tumors which stimulate proliferation. It is supposed that the test defining the peculiarities of the effect of erythrocytes on the proliferative capacity of tumor cells in the tissue culture can be used for the judgement about an individual activity of the growth of primary tumors as well as for the diagnostics of recidivation of tumor growth.

Animals↗

PubMed1984

[Influence of interferon on the toxic effect and antitumor activity of vinblastine in the combined therapy of metastatic Lewis carcinoma].

Antitumour and antimetastatic effects of the combination of vinblastine (VLB) and L-cell interferon were examined. It is shown that mice with 3LL carcinoma are more sensitive to common toxic effect of VLB than intact animals. Interferon (IF) decreases the toxic effect of VLB in tumour-bearing mice, and thus provides a possibility to increase the total therapeutic dose of the cytostatic. The combination of VLB and IF showed a synergistic inhibitory effect on the development of carcinoma metastases and significantly increases the survival rate of the tumour-bearing mice. Neither synergistic nor additive antitumour effects of the combined therapy were observed on the primary tumour. IF suppresses the primary tumour growth more significantly when given by intratumoural injection. At the same time the inhibition of metastase development was more efficient with intraperitoneal injection of IF.

Animals↗

PubMed1984

[Detection of chalones produced by a primary tumor in the blood of mice with Lewis carcinoma].

The substance fraction precipitated in 81% ethanol from blood or tumour tissue of mice with Lewis (3LL) carcinoma on the 13th, 20th and 32nd day after the tumour transplantation is established to inhibit the processes of proliferation in the cell culture of the same tumour. The fraction isolated on the 7th day after transplantation stimulated the proliferation. No inhibition of proliferation was observed when studying the effect of the same fraction isolated on the 13th and 20th day from blood of mice with B-16 melanoma on the 3LL carcinoma. This fact suggests a tissue-specific action of proliferation inhibitors isolated from blood of mice with Lewis 3LL carcinoma and permits considering them as chalones. An assumption is advanced that the primary tumour synthesizing chalones and secreting them into blood can regulate not only its own growth but also the growth of remoted metastases.

Animals↗

PubMed1983

[Determination of the mitotic index in tumors by using cell suspensions].

A new variant of the method for mitotic index determination is offered. For this, a tumor cell suspension is obtained by treating the tumor with a 0.3% trypsin solution. Then the cells are transferred to a hypotonic solution where these undergo lysis and, in result, the nuclei are seen to be released in the medium. The ratio of nuclei being in meta- and anaphase is determined. Determination of the mitotic index in tumors using this method allows to avoid a technical error associated with the fact that the proliferative activity is not uniform in different parts of the tumor.

Animals↗

PubMedDate not supplied

[Short-term outcomes of radical surgery for bladder cancer].

A total of 102 radical cystectomies have been conducted for 1996-2001 (94 males, 8 females, age 37-78 years, mean age 57.5 years). Most of the patients (81.4%) were diagnosed to have transitional cell carcinoma. Supravesical urine derivation was made by means of ureterocutaneostomy and transureteroureteronephrostomy in 7(6.9) patients, ureterosigmoanastomosis--in 41(40.2%), Sigma-rectumpouch--in 1(0.9%) patients, ileocystoplasty, largely by Hautmann and Studer was carried out in 52(51%) patients. Postoperative complications developed in 25(24.5%) patients who often had adhesive ileus. Four patients died: 2 of pulmonary artery thromboembolism, 1 of acute cardiac failure and 1 of sepsis. Methods of continence urine derivation were preferred, such as ureterosigmoanastomosis by Mainz-Pouch II and creation of orthotopic bladder of the ileum.

Adult↗

PubMedDate not supplied

[Short-term results of radical cystectomy].

The paper presents the results of 114 radical cystectomies made in 1996-2002. The age of 114 patients (103 males, 11 females) ranged from 37 to 78 years (mean age 57.5 years). Transient cell carcinoma was diagnosed in 81.5% patients. Supravesical urine derivation was conducted by means of ureterocutaneostomy and transureteroureteronephrostomy in 9 (7.9%) patients, ureterosygmoanastomosis--in 43 (37.7%) patients, artificial orthotopic urinary bladder was created in 7 (6.1%) patients of a gastric segment and in 55 (48.2%) patients of the ileum. Postoperative complications were observed in 28 (24.6%) patients, intestinal obstruction being a prevailing complication. Five patients died: 2 of pulmonary artery thromboembolism, 1 of acute cardiac failure, 1 of sepsis and 1 of gastric bleeding. Continent methods of urine derivation were preferred, such as ureterosygmoanastomosis by Mainz-Pouch II and creation of orthotopic urinary bladder of the stomach or of the ileum.

Adult↗

PubMedDate not supplied

[Urodynamics of artificial urinary bladder].

Radical cystectomy with creation of orthotopic reservoir from various segments of gastrointestinal tract was made in 120 patients (99 males, 21 females, age 37-74 years) with muscular-invasive cancer of the urinary bladder (UB) in 1996-2004. Replacement of UB was made according to the Studer and Hautmann method in 38 and 27 patients, respectively. S-cystoplasty was performed in 31 patients. The gastric segment was used for creation of the reservoir in 24 patients. Three patients died. Three to twelve month follow-up recorded the best functional results in patients after Studer cystoplasty.

Adult↗