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Biomedical subjects

V A Fradkin

Publications and source records attributed to V A Fradkin.

At least 19 recordsLinked to original sources
PubMed1992

[A comparative immunochemical analysis of allergoids and allergens].

In comparison with allergens having protein fragments with a molecular weight not exceeding 110 kD, allergoids have been found to consist of larger fragments with a molecular weight of 10-150 kD. Allergoids have less charged components than initial allergens and less antigenic components. Allergoids retain their capacity for stimulating the production of antibodies, specific to all antigenic components.

Allergens↗
PubMed1991

[The comparative characteristics of different forms of allergens from mites of the genus Dermatophagoides].

The comparative study of allergenic preparations of Dermatophagoides mites [correction of ticks] from different manufacturers and the international standard preparations of such allergens was made. D. pteronyssinus and D. farinae allergens from the USSR and the Netherlands were studied. The samples under study were evaluated in a complex of in vivo and in vitro experiments. The preparations produced in the USSR and in the Netherlands exhibited pronounced specificity, but the allergens of both species from the Netherlands were more active. Some differences in the immunochemical characteristics of the preparations were noted.

Adolescent↗
PubMed1990

[Evaluation of allergy to conditionally pathogenic fungi].

Sensitization to Candida albicans, Mucor, Cladosporium, Penicillium, Alternaria, Rhizopus nigricans was studied in vitro and in vivo in patients suffering from allergic diseases. The overwhelming majority of the positive responses to skin tests were of the immediate type. In parallel with the immediate responses, delayed ones were recorded in some patients. Positive responses in radioallergosorbent test and in estimation of the neutrophil injury index according to V. A. Fradkin did not always correlate with the skin test results. High titers of total IgE in some cases did not coincide with the titers of specific antibodies.

Adolescent↗
PubMed1990

[The immunochemical characteristics of allergens].

Modern approaches to the standardization of allergens require the use of not only biological methods, but also a wide range of physicochemical and immunological ones. To obtain Soviet standard samples, the optimum spectrum of methods for their characterization, evaluation and comparison with international standard samples should be definitely selected. After the preliminary study of a number of allergens by different immunochemical methods a set of such methods, including different kinds of electrophoresis, isoelectrofocusing, immunoblotting, etc., are proposed, these methods being considered obligatory for obtaining Soviet standard samples of allergens.

Allergens↗
PubMed1987

[Use of isoelectric focusing for assessing the composition of pollen allergens].

The preparations of allergens and allergoids obtained from ragweed, timothy and wormwood pollen, as well as the preparations of allergens from birch and orchard grass pollen differing in the method of their production, have been studied with the use of analytical isoelectric focusing in a thin gel layer. The composition of the preparations of allergoids differs from that of the allergenic preparations from the pollen of the same plant species by the decreased content of protein components detected in this investigation. The main proteins contained in the preparations of allergoids are distributed in the zone of pH 3.5-4.5. Differences in the composition of different batches of the same allergens, manifested by variations in some protein bands or by their absence, have been noted. Protein components with the isoelectric point in the alkaline zone have been detected only in the preparations of ragweed pollen allergens.

Allergens↗