PubMed Health⌕ Search

Biomedical subjects

V A Gorshkov

Publications and source records attributed to V A Gorshkov.

At least 19 recordsLinked to original sources
PubMed2005

[Muriatic secretion and acid-proteolytic activity of the stomach in vivo].

The study of the basal (BAP) and stimulated (SAP) acid production effect on the average daily acidity and speed of proteolysis in the stomach in vivo was conducted in 498 patients with various functional states of the stomach. It was established that the aforesaid muriatic secretion indices influence the acidity and speed of proteolysis in natural conditions of digestion only within the low and normal range of their values. In the condition of HCl hypersecretion, the dependence between the muriatic secretion and acidity and proteolytic stomach activity in vivo gets lost. This can be explained by the autoregulation effect supporting the introgastral pH optimal for pepsin activity irrespective of the intensity of the acid glands hyperplasia.

Adolescent↗
PubMed2002

[Problems of functional study of the stomach in contemporary gastrology].

In the assessment of the functional state of the stomach the interest to its secretory functioning has remained constant and in the center of attention of physiologists and clinicians during the past century. That is understandable. After all, the level of secretion of gastric juice enriched with the acid and pepsins defines numerous aspects in the functioning of this organ and its peptic, bactericidal and even evacuation functions. Moreover, under certain conditions active gastric juice can turn from a mediator in the normal peptic process into a solely pathogenetic factor and promote the development of a number of so-called acid-dependent diseases that have conventionally included stomach ulcer, reflux-esophagitis, postgastrectomy ulcers of the anastomosis and other more infrequent pathological states. A distinct positive reaction to the application of anti-acid preparations is common for all these diseases. At the same time, the role of HCI in their development remains comprehensible only in some aspects.

Gastric Acid↗
PubMed2001

Superheavy hydrogen (5)H.

Experimental search for (5)H using a secondary beam of (6)He has been performed. The transfer reaction (1)H((6)He,(2)He)(5)H was studied by detecting two protons emitted from the decay of (2)He. A peak consistent with a (5)H resonance at 1.7+/-0.3 MeV above the n+n+t threshold was observed, with a width of 1.9+/-0.4 MeV. The angular distribution of the (1)H((6)He,(2)He)(5)H reaction was measured as well as the energy correlation of the two protons.

Journal Article↗
PubMed1997

Restriction endonuclease analysis of highly repetitive DNA as a phylogenetic tool.

Multiple band patterns of DNA repeats in the 20-500-nucleotide range can be detected by digesting genomic DNA with short-cutting restriction endonucleases, followed by end labeling of the restriction fragments and fractionation in nondenaturing polyacrylamide gels. We call such band patterns obtained from genomic DNA "taxonprints" (Fedorov et al. 1992). Here we show that taxonprints for the taxonomic groups studied (mammals, reptiles, fish, insects-altogether more than 50 species) have the following properties: (1) All individuals from the same species have identical taxonprints. (2) Taxonprint bands can be subdivided into those specific for a single species and those specific for groups of closely related species, genera, and even families. (3) Each restriction endonuclease produces unique band patterns; thus, five to ten restriction enzymes (about 100 bands) may be sufficient for a statistical treatment of phylogenetic relationships based on polymorphisms of restriction endinuclease sites. We demonstrate that taxonprint analysis allows one to distinguish closely related species and to establish the degree of similarity among species and among genera. These characteristics make taxonprint analysis a valuable tool for taxonomic and phylogenetic studies.

Animals↗
PubMed1997

[Sotahexal pharmacodynamics in patients with ischemic heart disease].

Therapeutic and prophylactic antiarrhythmic efficacy of sotalol hydrochloride (Sotahexal, "Hexal", Germany) and its effects in intracardiac hemodynamics and ECG parameters were evaluated in 95 patients with ischemic heart disease (IHD). The highest response to the drug was observed in ventricular extrasystoles, arterial flutter and fibrillation. Acute episodes of arrhythmia are managed by bolus administration of Sotahexal [correction of Hexal]. In this case greater risk of side effects exists. It is desirable to decide on the drug dose, mode of administration on the individual basis with due consideration of the risks and dangers which could be avoided in case of adequate instrumental control.

Adrenergic beta-Antagonists↗
PubMed1995

[Use of bonnecor in the treatment of ventricular arrhythmia].

The effectiveness of the new antiarrhythmic drug bonnecor was tried in 59 patients with ventricular arrhythmia. High antiarrhythmic activity of the drug was recorded in the course doses 150 to 250 mg/day. Bonnecor effect is dose-dependent: the number of ventricular extrasystoles reduced by 75% in 62 and 74% of the patients receiving 150 mg/day and 20 mg/day, respectively. The highest effect was achieved in high-grade ventricular extrasystole. Side effects were occasional: headache lasting 1-2 hours 40-50 min after bonnecor administration, slow atrioventricular conduction (2 cases), sleep disorders (2 cases).

Adult↗
PubMed1994

[The pharmacodynamic and ulcer-healing action of modern anti-ulcer agents].

In a study of 159 duodenal ulcer patients the authors studied the effect of H2-blockers, antibacterial and sucralfate monotherapy on the frequency of the ulcer healing, Helicobacter pylori (HP) infection and acid-proteolytic aggression in the body and antropyloric portion of the stomach. All the drugs were found to exhibit similar antiulcer activity. Inhibition of the acid-proteolytic aggression in the gastric body was registered only under the action of H2-blockers. Antibacterial preparations inhibited the growth of HP, but did not affect the acidity and proteolysis in the gastric body. Neither did sucralfate which also had no effect on microorganisms. All the test drugs were able to reduce antropyloric acidity, thus promoting healing of the ulcer.

Adolescent↗
PubMed1993

[The pharmacodynamics of the new anti-arrhythmia preparation bonnecor based on the data from an acute drug test].

The pharmacodynamics of the new antiarrhythmic agent bonnecor was studied in 33 patients with coronary heart diseases and ventricular arrhythmias in the acute drug test. The parenteral formulation of the drug (0.04-0.8 mg/kg) and its tablets were given to 23 and 27 patients, respectively. Bonnecor was found to be effective in suppressing ventricular premature contractions. Its intravenous and oral efficacy is 65 and 70%), respectively. During intravenous injection, the drug showed its antiarrhythmic effect on an average of 14 minutes later, lasting about 68 minutes. During oral administration, the action of the drug started 0.5 hour later and lasted 7.2 hours. Adverse reactions were rare. An echocardiographic study revealed its negative inotropic effect which is likely to be insignificant since there was no development or increase of heart failure in any of the examinees (including 8 patients with signs of Stage I-IIA circulatory insufficiency).

Adult↗
PubMed1991

[Effect of ethacizine on the heart conduction system and the indicators of central hemodynamics].

A trial of the antiarrhythmic drug ethacizine made in the Soviet Union which is an analogue of ethmozine was performed in 38 patients suffering from coronary heart disease. Automatism, conduction and excitation of the myocardium, hemodynamics and the antiarrhythmic effect were studied using electrophysiological methods, echo-cardiography and Holter monitoring. Ethacizine was found effective in arrhythmia. It reduces conduction in small changes of hemodynamics and myocardial contractility.

Adult↗
PubMed1990

[Assessment of anti-arrhythmic activity of palpitin and cardio-hemodynamic effects of its administration].

Palpitin, an agent of the disopyramide series, was evaluated for its antiarrhythmic potency in the treatment of ventricular and supraventricular arrhythmias and for its effects of ECG and central hemodynamic parameters in 108 patients (91 had coronary heart disease, 8 presented with postmyocardial cardiosclerosis, 5 had hypertensive disease, and 4 suffered from neurocirculatory dystonia). 24-hour ECG monitoring and echocardiography were employed in the study. It was concluded that the drug possessed a high antiarrhythmic potency. No substantial changes were found in the mean values of echocardiographic parameters, as well as of atrioventricular and intraventricular conduction.

Adolescent↗
PubMed1990

[Antibiotics as proteolysis inhibitors in the stomach].

The study was made of antibiotics action on hydrolysis of coagulated protein in gastric juice. It was established that antibiotics can produce inhibition of protein proteolysis in gastric juice. The highest antiprotease activity was reported for cephalosporins , rifampicin and penicillins, the lowest for tetracycline++. Antiprotease activity of antibiotics should be taken into consideration when defining their therapeutic effect in peptic ulcer.

Anti-Bacterial Agents↗
PubMed1989

Platelet aggregation and prostaglandin metabolites in the blood of patients with ischaemic heart disease during antiarrhythmic treatment.

The influence of antiarrhythmic drugs (oral lidocaine, palpitine, Etacizine) on blood platelet aggregation and prostaglandin metabolites was studied in 91 patients with ischaemic heart disease. Lidocaine showed a positive, Etacizine a negative, and palpitine no effect on platelet aggregation. There was no uniform effect of lidocaine on prostaglandin metabolites; it increased the prostacycline and decreased the thromboxane levels. Palpitine increased both prostacyclin and thromboxane levels, whereas Etacizine decreased both metabolites, especially prostacyclin.

Adult↗
PubMed1989

[The intestinal type of digestion in the stomach of patients with chronic gastritis and secretory insufficiency].

The authors studied the acid-proteolytic profile of the stomach using an original method in 9 patients with superficial gastritis, in 38 patients with atrophic gastritis and in 25 of the control group without gastroduodenal pathology. It was established that in patients with atrophic gastritis associated with secretory insufficiency, proteolytic activity is maintained due to entering of pancreatic enzymes in the process of digestion and is characterized by an increase of the intensity of proteolysis from the cardia to the pylorus, by low values of hydrolysis of proteins resistant to the effect of pancreatic proteinases.

Adolescent↗