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Biomedical subjects

V A Iakovlev

Publications and source records attributed to V A Iakovlev.

At least 19 recordsLinked to original sources
PubMed1998

[Renin-aldosterone system in secretion of cortisol in patients with arterial hypertension in European North].

Renin activity (RA), concentration of aldosterone and hydrocortisone in plasma were measured by radioimmunoassay in 78 males with arterial hypertension living in the Far North. RA and aldosterone concentrations were high in patients with borderline arterial hypertension irrespectively of hemodynamic type of the disease. Hydrocortisone levels in them were normal. In hypertension stage I and II RA and hydrocortisone concentrations were normal, while aldosterone levels have risen. Renin-aldosterone index showed high RA in all hemodynamic types of hypertension.

Adult↗
PubMed1997

[The place of fasting therapy in the treatment of hypertension].

The study of changes in cardiovascular system and its regulation mechanisms occurring in 150 hypertension stage II patients on fasting diet has established the following phenomena: inhibition of the basic metabolism and generation of energy leading to low activity of central mechanisms regulating hemodynamics and reduced adaptability of such mechanisms, weakening of sympathetic influences on the myocardium and smooth muscle cells of the resistant vessels, their reduced contractility as a result of decreased calcium concentration and energy production in the cells.

Adult↗
PubMed1996

[Chronostructure of ectopic heart activity in the acute phase of myocardial infarction].

7-day monitoring of cardiac rhythm has been conducted in 42 patients with myocardial infarction (MI) and 15 patients with chronic ischemic heart disease. Hour-by-hour analysis of extrasystole demonstrates that probability of ventricular arrhythmia is maximal in transmural MI, the first 3 days of acute MI are most arrhythmogenic. Follow-up of ventricular ectopic activity (VEA) showed the latter to significantly enhance early in the morning, afternoon and on the first 5 days after midnight. In unpenetrating MI, VEA intensifies in the morning, afternoon and postmidnight hoars. Atrial ectopic activity (AEA) in transmural MI enhances early in the morning, afternoon and at night (on the first 3 days). AEA in unpenetrating MI is more intensive late in the morning and afternoon.

Acute Disease↗
PubMed1994

[The mechanisms of the therapeutic action and the basis for the frequency of performing sessions of ultraviolet blood irradiation in treating acute pneumonia. 1].

Mechanisms of therapeutic action of UV blood irradiation and optimal irradiation scheduling were studied in the course of UV-irradiated blood transfusions capable of correcting lipid peroxidation (LPO) and antioxidant system (AOS) in acute pneumonia (AP) patients. Single and multiple measurements of LPO and AOS parameters (malonic dialdehyde, diene conjugates, red cell resistance to peroxide hemolysis, catalase, superoxide dismutase, cerulloplasmin, plasma total estrogens, progesterone and testosterone) were made in 10 young males with moderate AP and 20 healthy controls. UV blood irradiation in AP is shown to be pathogenetically validated. It works via effective stabilization of LPO as a result of early adequate stimulation of endogenic AOS. Positive changes were also induced in the system of hormonal regulation. It is suggested that hyperestrogenemia plays a compensatory role in AP pathogenesis.

Acute Disease↗
PubMed1992

[The metabolism of eicosanoids, glucocorticoids and cyclic nucleotides in young people with acute pneumonia].

An investigation into the pathogenesis of acute pneumonia in 37 young men made it possible to ascertain the role of arachidonic acid metabolites and hormonal regulation in the pathogenesis of the inflammatory reaction in acute bacterial pneumonia. At the initial stage of inflammation, invasion of the infectious agent leads to phagocytosis activation, stimulates the output of immunoglobulins belonging to different classes, which, binding antigens, form immune complexes influencing the output of biologically active substances. This is accompanied by the destruction of pulmonary tissue, release of lipid peroxidation radicals and proteinases, by the enhancement of arachidonic acid degradation under the destructive action on the membranes of phospholipase A2 cells to form prostaglandins participating in the changes in the tone of bronchi, pulmonary vessels and affecting blood coagulation. Activation of the hypophyseo-adrenal system leads to the attenuation of the effects produced by biologically active substances and exerts varying actions in the acute and convalescence periods. The data obtained stress an important role played by metabolic functions of the lungs in the integrative connections of all the systems of the body maintaining homeostasis in pneumonia and the main function of the lungs, namely ventilation.

Acute Disease↗
PubMed1991

[Ultraviolet irradiation of autologous blood in the complex treatment of patients with diabetes mellitus].

A single reinfusion of UV-irradiated autologous blood was performed in 76 patients with non-insulin-dependent (NID) and insulin-dependent (ID) diabetes mellitus. Lipid peroxidation (LPO), activity of glycolysis and pentose cycle principal enzymes, red cell cyclic nucleotides, hormones concentrations, glucose utilization were investigated. It is shown that general physiological action of UV radiation is primarily due to LPO stimulation responsible for changes in cell membrane properties. This action may vary with baseline LPO characteristics. UV radiation is valid in combined therapy of NID diabetes mellitus as it activates intracellular metabolism, reduces concentration of ++contra-insular hormones, improves tissue utilization of glucose. ID diabetes mellitus is contraindication for UV radiation use as additional stimulation of initially high LPO entails inhibition of activity of intracellular enzymatic systems participating in glucose metabolism, leads to low production of endogenous insulin.

Adult↗