[The role of intracellular viremia and disorders of the monocyte functional activity in the pathogenesis of acute pneumonia].
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Biomedical subjects
Publications and source records attributed to V A Ignat'ev.
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A study was made of the content of protease alpha 1-inhibitor and of the phenotyping of protease alpha 1-inhibitor subtypes in 666 patients with different chronic non-specific pulmonary diseases. It is concluded that pronounced deficiency of protease alpha 1-inhibitor is of importance in the formation of primary emphysema, chronic obstructive bronchitis and bronchial asthma. The clinical characteristics of obstructive pulmonary diseases marked by protease alpha 1-inhibitor deficiency have been investigated.
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Clinical and cardiorespiratory findings in patients with chronic obstructive pulmonary disease (COPD) stage I and IIA and the results of exercise tolerance tests in patients with mild and moderate bronchial asthma (BA) at a remission stage were studied for effects of positive oscillatory expiratory pressure created in respiration through flatter on exercise adaptation. It was proved that breathing through flatter before exercise tolerance test raises tolerance to exercise in COPD patients, modifies a cardiorespiratory response in direction of its optimization and lowers nonspecific bronchial hyperreactivity in BA patients.