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V A Kipiani

Publications and source records attributed to V A Kipiani.

8 recordsLinked to original sources
PubMed2006

Changes in the prooxidant and antioxidant status of tissues during paraneoplastic processes.

Electron paramagnetic resonance was used to identify paramagnetic centers in the blood and liver of laboratory rats with S-45 sarcoma and mice with Ehrlich carcinoma. Paraneoplastic changes in prooxidant and antioxidant activity of the blood and liver tissue, mitochondrial respiration, and NO metabolism and inhibition of antioxidant processes contribute to impairment of cell membrane structures, erythrocyte hemolysis, and hypoxia. An important role of these processes in the pathogenesis of paraneoplastic anemia is confirmed by the positive effect of antioxidant and membrane-stabilizing therapy.

Anemia↗
PubMed2006

[Relationship between lipid peroxidation processes, blood vessel wall changes and properties of erythrocytes in pathogenesis of microhemocirculation disorders during experimental diabetes mellitus].

The microhemocirculation play the main role in the development of the micro-and macroangiopathy during Diabetes Mellitus. The aim of our work was to study changes of free-radicals and deformability of erythrocytes using the filtration-photometric and electronic-paramagnetic methods in white rats during Alloxan Diabetes at different stages. Erythrocytes deformability was estimated by the time needed for erythrocytes passage through the filter and state of blood and blood vessels walls were studied by the EPR method. It had been detected that erythrocytes deformability sharply reduced and blood vessels wall was damaged by activation of lipid peroxidation and inhibition of antioxidant system, which may lead to disorders of microhemocirculation.

Animals↗
PubMed2005

[Oxidative stress as common pathological phenomenon and possibilities of its correction].

It was shown that disorders of oxidative metabolism play an important role in the pathological processes which develops at subcellular level -- disorder of electron transport at ubichinon-oxidoreductase locus of respiratory chain in mitochondria. The latter could be discussed as common pathological phenomenon determining oxidative stress. It is found that altered synthesis and metabolism of nitric oxide plays an important role in the pathogenesis of oxidative stress. It has been detected the ways and mechanisms of disorders of NO synthesis and conversion. The negative role of widespread and irrational use of antioxidant therapy and "universal" antioxidant treatment was characterized.

Antioxidants↗
PubMed1988

[Systemic arterial pressure and characteristics of its changes in response to hypertensive agents in tumor-bearing animals].

Arterial pressure (in the carotid artery determined by electromanometry) and total peripheral resistance (changes in the clear space of resistive arteries of the mesenterium, skeletal muscles and mammary glands measured by biotelemicroscopy) were studied in tumor-bearing animals (random bred, BALB/c and CBA mice with Ehrlich carcinoma). With the growth of hypodermic injected tumor, it has been shown that the arterial pressure first dropped and then there was a tendency towards normalization, but the pressure never reached the initial level. At the same time arterial dilatation took place, especially at the first stage of tumor growth. This shows the dependence of changes in arterial pressure on the clear space of resistive arteries. It was also revealed that changes in the vascular tone were connected with the functional disturbances of adrenoactive structures but not with reduced myocyte contractility.

Angiotensin II↗
PubMedDate not supplied

[The role of changes in tissue redox-status in mechanism of paraneoplasia].

To specify mechanisms of paraneoplastic alterations of redox-status of tissues in experimental malignant tumor growth, we investigated electronic paramagnetic centers of blood, skeletal muscle and liver with electronic paramagnetic resonance (EPR) method. We also studied the concentration and activity of antioxidant enzymes. Our experiments on adult white male rats of mixed population with sarcoma C-45 and mice with Ehrlich carcinoma have shown that malignant tumor growth leads to enhanced lipid peroxidation (LPO): production of potent LPO promoters - Fe2+, Mn+2+, NO, ubiquinone; depression of antioxidant defence - reduced production of total ceruloplasmin, elevated blood levels of oxidized ceruloplasmin and enhanced catalase activity. It is suggested that malignant tumor growth is associated with marked paraneoplastic shifts in tissue redox-potential. These alterations are involved in mechanisms of paraneoplastic changes of red cells, microhemocirculation and circulation intensity. All these interrelated processes result in generalized paraneoplastic hypoxia of the organs and tissues. Basing on our and literature data, we propose an original scheme of the mechanisms of paraneoplastic disorders of tissue redox-status, microcirculation and erythrocytes.

Animals↗