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Biomedical subjects

V A Kubyshkin

Publications and source records attributed to V A Kubyshkin.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Antienzyme function of the lungs in acute pancreatitis].

Experiments were made on 22 anesthetized dogs to examine the systemic and pulmonary hemodynamics, gas exchange and metabolic pulmonary function in pancreonecrosis. Metabolic pulmonary function was evaluated from arteriovenous difference according to elastase. In the early stages of experimental pancreatitis, the lungs were shown to inactivate elastase and to function as an active metabolic organ. Then depletion of antienzymatic pulmonary function is observed, which is accompanied by decompensation of the hemodynamics and gas exchange. Abnormality of antienzymaztic pulmonary function plays an important role in the pathogenesis of acute pancreatitis.

Acute Disease↗
PubMed1982

[Potentials of transhepatic catheterization of the portal vein in diagnosing and treating surgical diseases].

Questions of the application of paracentetic transhepatic catheterization of the portal vein performed from the lateral access are dealt with. Indications for its application are discussed. Morphological changes and disturbances of hemodynamics of the portal system in certain diseases of the abdominal cavity are analyzed. Possible application of catheterization of the portal vein with curative purposes in order to stop oesophageal hemorrhages in portal hypertension and for continuous antienzymatic therapy of pancreonecrosis is shown.

Adult↗
PubMed1980

[Elastase activity in experimental pancreatitis].

The activity of elastase, elastase inhibitor and isozymes of lactate dehydrogenase (LDH) was studied in 11 dogs with experimental pancreatitis and 5 control dogs. All dogs with experimental pancreatitis died 6--14 hours after the induction of pancreatitis. Morbid anatomy studies proved severe pancreonecrosis. The results obtained show that after the induction of pancreatitis the elastase blood activity increased 3-fold as compared with the initial level, and remained unchanged up to the animals' death. At the same time the activity of elastase inhibitor fell, correlating with the rise in elastase activity. Also there was a disproportion between LDH 1 and LDH 2 which became more conspicuous to the 3d hour, and an increase in LDH 5 by the end of the experiment. A conclusion is made that dysfunction of the liver may be one of the causes of the decreased inhibitory activity of elastase in pancreonecrosis.

Animals↗