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Biomedical subjects

V A Liusov

Publications and source records attributed to V A Liusov.

At least 19 recordsLinked to original sources
PubMed1997

[Free radical oxidation in patients with hypertrophic cardiomyopathy].

As shown by the study of 27 patients with non-obstructive form of hypertrophic cardiomyopathy (HC), this disease is associated with a significant rise in the production of active oxygen forms by leukocytes, significant changes in the activity of enzyme antioxidant defense, unchanged lipid peroxidation, high total antioxidant activity of blood plasma. The patients received a complex of natural antioxidants varying by mechanism of action and glutaminic acid. Antioxidants produced a subjective clinical response, reduced incidence of cardiac arrhythmia, improved exercise tolerance. The response becomes still better in combination of antioxidants with conventional therapeutic tools.

Adult↗
PubMed1995

[The joint use of plasmosorption and enterosorption in the combined treatment of patients in the acute period of a myocardial infarct].

Plasmosorption and enterosorption were assigned to 35 acute myocardial infarction (AMI) patients. Plasmosorption was performed within an hour since AMI onset followed by a 5-day course of enterosorption (enterosorbent YO-A in a dose 30 g/day). The above combination produced a positive effect on hemodynamics and blood rheology resultant from a reduction in hematocrit value, plasma levels of fibrinogen and its derivatives, plasma viscosity and platelet aggregation. Ibustrin (200 mg) combined with heparin (100000 U) introduced into extracorporeal circulation effectively prevents thrombogenesis. AMI patients treatment with enterosorption plus plasmosorption enhances the response to nitroglycerin, reduces the rate of complications and lethal outcomes.

Analysis of Variance↗
PubMed1992

[Role of imbalance of sex hormones and gonadotropins in the development and course of essential hypertension in women].

Overall 146 females suffering from essential hypertension (borderline, stage I and II according to WHO, 1980) were examined for basal concentrations of estradiol, estriol, progesterone, testosterone, cortisol, ACTH, prolactin in plasma, LH and FSH in blood and urine. The patients and 69 control normotensive females were reproductive, premenopausal, menopausal, postmenopausal, postcastration. Latent hypertension was elicited at bicycle exercise. It was found that relationships between sex hormones and gonadotropins both in hypertensive and normotensive women did not differ noticeably in reproductive period and in menopause. Hormone defects due to primary and secondary infertility, castration, menopause did not raise the risk of arterial hypertension onset. An-Unfavorable course of hypertension was observed in premenopause, following operative castration, in climacteric syndrome. The severity of AH at reproductive age was associated with hyposecretion of progesterone, estrogens and gonadotropins LH, FSH. This relationship was absent in menopausal women. A conclusion is proposed on miner significance of sex hormones imbalance and gonadotropins in the onset of arterial hypertension in females varying by generative activity.

Adrenocorticotropic Hormone↗
PubMed1992

[Effects of laser therapy in patients with functional class II-IV effort angina (using instrumental techniques of the study)].

Infrared laser therapy using an arsenide-gallium laser was used in 54 patients aged 30-75 years who suffered from coronary heart disease. A positive clinical effect was achieved in 47 (87%) of 54 patients, as evidenced by the reduced number of nitroglycerin tablets used and improved bicycle ergometric, echo- and electrocardiographic parameters in the patients.

Adult↗
PubMed1990

[Differences in metabolic rate of Na+/H+ in the erythrocyte membrane in hypertension and symptomatic hypertension of renal origin].

Na+/H+ turnover rate in the erythrocyte membranes were measured in 20 patients with Stages II and III essential hypertension, 11 patients with renal hypertension and 10 healthy subjects. The patients with essential hypertension showed a two-fold increase in Na+/H+ turnover rate as compared to the controls. Those with renal hypertension displayed no changes in the rate. The rate of Na+/H+ turnover was not associated with the patients' sex and was the same in Stages II and III essential hypertension. Measuring the Na+/H+ exchange rate was proposed to be an additional diagnostic tool for the differential diagnosis of arterial hypertension.

Adolescent↗
PubMed1989

[Use of prolecofen in the treatment of arrhythmia in patients with ischemic heart disease].

A new antiarrhythmic drug, prolecofen (class Ic), was used in 74 patients with various forms of coronary heart disease, involving heart rhythm disorders. The drug's clinical efficiency and effects on platelet activity, lipid peroxidation, blood prostacyclin, thromboxane, cAMP and cGMP were assessed. Prolecofen is shown to be an effective agent for the treatment of ventricular and supraventricular arrhythmias in coronary patients. It contributes to the inhibition of platelet activity, a drop of cAMP and cGMP levels and a rise of the cAMP/cGMP ratio.

Adult↗
PubMed1989

[Effects of nirmin on central hemodynamics in patients with heart failure in the acute period of myocardial infarct].

Nirmin, a novel dosage form of nitroglycerin, was used to treat heart failure in 47 patients on days 1-3 after acute myocardial infarction. The drug was intravenously injected at 12-400 micrograms/min for 3-24 hours. Central hemodynamic changes were evaluated from equilibrium radionuclide ventriculographic data and pulmonary diastolic and central venous pressures. Nirmin improved the clinical status in 89.3% of the patients. Hemodynamic effects of the agent were manifested by reduced myocardial preload and its improved contractility, followed by elevated left ventricular ejection fraction and decreased hypokinesia of the myocardial affected areas.

Adult↗
PubMed1989

[Vascular mechanisms of disorders of rheological properties of the blood in patients with myocardial infarction].

The contribution made by vascular factors to impairment of blood rheological properties was demonstrated on the basis of examination of 65 apparently healthy persons by using a vascular occlusion test. The vascular endothelium showed a decrease in fibrinolytic, anticoagulant, antiaggregatory activities. The new term "hemorheological tolerance to vascular occlusion" was proposed to use. A number of quantitative and qualitative indices for normal hemorheological tolerance were identified. The paper provides data on the frequency of particular mechanisms responsible for its decrease. It also emphasizes that the knowledge of the mechanisms of vascular impairments makes it possible to choose a combined drug therapy for myocardial infarction in a differential fashion.

Adult↗