Biomedical subjects

V A Maleev

Publications and source records attributed to V A Maleev.

2 recordsLinked to original sources

PubMed2006

[The growth constraining diet causes various strategy of adaptation in young and adult animals].

The glucose-6-phosphatase activity of microsomes and phosphorylative mitochondrial activity of liver cells, alanine- and aspartate aminotransferase activities in plasma of blood of young (3 month) and adult (21 month) male rats kept under three various diets resulting in a various degree of a growth inhibition and losses of weight of a body have been studied. There were selected diets giving to animals the food full-valued by composition but limited by quantity. Experiment proceeded 50 days. It was found out various metabolic strategy of adaptation in young and adult animals in reply to this influence. Experimentally this phenomenon revealed itself in various correlations between researched metabolic parameters at young and adult rats. Activity of researched enzymes in adult animals changed in a greater degree in comparison with a base level than at young ones. Researchers suppose that the revealed distinctions of metabolic strategy of adaptation in young and adult animals can be attributed to their generated epigenotypes.

Adaptation, Physiological↗

PubMed2004

[Does the liver ability to regeneration decrease with age? The dynamics of functional activity of mitochondria in process of the liver regeneration].

The ability of liver of 1-, 3-, 12- and 24-month rats to mass restoration, mass gain and activity of cell energy system from 1 to 30 days after ectomy of liver medial and left lateral lowels were investigated. It was shown that the old animals did not rebate to young ones in respect of regenerant gain and exceeded them with mitochondria functional activity at the early stages of regeneration (2-24 h after operation). We detected a little lag in old rats (12 and 24 monthes) in comparison with 1-3 ones in rate of liver mass reset to corresponding age groups control level. It may be explained by the difference between young and old animals in strategy of organism homeostasis after ectomy of 2/3 liver mass. The rhythmic character of activities for the most of indices of mitochondria functional activity in liver regenerating up to 24 h with maximum at 2-3 h and 12-18 h after operation was detected. The detected rhythm was typical mostly to mitochondria of the old animals. The high functional activity of mitochondria of the old animals and on the late stages of liver regeneration was shown.

Adenosine Diphosphate↗