PubMed Health⌕ Search

Biomedical subjects

V A Mikhaĭlov

Publications and source records attributed to V A Mikhaĭlov.

At least 19 recordsLinked to original sources
PubMed2003

[A novel laboratory method of isolation and purification of tobramycin].

A new laboratory method for isolation and purification of tobramycin by using extraction of a tobramycin derivative with benzaldehyde by methylene chloride, subsequent hydrolysis of azomethine and recrystallization of the formed tobramycin sulfate from solution of sulfuric acid in methanol was developed. The method allows to exclude the stage of chromatographic purification of tobramycin, to reduce the time of the process realization from 120-125 h to 15-20 h, to increase the yield of the target product from 37-40% to 60-65% without decreasing the product quality, to exclude a number of large-size and expensive equipment and to ensure high reproducibility of the technology.

Anti-Bacterial Agents↗
PubMed2003

[Fermentative hydrolysate of mycelial waste of aminoglycoside antibiotics production as component of culture media used in biosynthesis of tobramycin].

New nutrient media for cultivation of the tobramycin-producing organism were developed. As an additional source of nitrogen the media contain fermentative hydrolysate of the mycelial waste of manufacture of aminoglycoside antibiotics (tobramycin and apramycin). The use of the media provided a 20 to 50% decrease of consumption of soybean meal, an essential food raw material, and design of a low-waste technology for biosynthesis of tobramycin.

Anti-Bacterial Agents↗
PubMed2002

[Quality of life and rehabilitation of epileptic patients].

The quality of life (QL) study has been conducted using the WHOQOL-100 questionnaire in 146 patients with epilepsy in the process of their rehabilitation. Before treatment and restorative interventions, the majority of the patients evaluated their QL as moderate and low depending on the type, frequency and severity of seizures as well as on the age of the disease onset. During restorative therapy, the QL scores increased in physical, psychological and social relationship domains and some indices correlated with the results of restorative treatment.

Adolescent↗
PubMed2002

[Medico-social aspects of risk factors impairing quality of life in patients with epilepsy].

The results of 2-year multicenter project "Epilepsy, risk factors and insurance" organized by Epilepsy European Commission, on risk factors deteriorating quality of life of epileptic patients in 9 European countries (Italy, Germany, Spain, Netherlands, England, Portugal, Estonia, Russia and Slovenia), have been used in the study. The "patient-control" pairs were matched for various features characterizing social aspects of epileptic patient's life (educational level, professional level and employment, marital status, driving abilities, sports, medical insurance) as well as medical events (concomitant diseases, medical complications, seizures, frequency of accidents, hospitalization, disablement indices, etc). Patients at low and high risk for quality of life impairment were defined. In Russia, the rate of these risk factors in epileptic patients corresponds in general to that in other European countries.

Accidents↗
PubMed2000

[The optimization of epilepsy therapy with finlepsin].

A clinical pharmacological study (270 patients) was made to optimize therapy of epilepsy with carbamazepines (finlepsin and its retard form). It was established that insufficient (standard) doses of finlepsin are often used, serum levels of the drug are not estimated, drug pharmacokinetics is not taken into account, maximum permissible doses of the drug are not reached. Estimation of the efficiency of both preparations in the treatment of various types of the seizures was carried out. The advantages of finlepsin-retard were demonstrated.

Adolescent↗
PubMed1990

[Characteristics of angiohepatography using an oily contrast medium in the diagnosis of hepatic echinococcosis].

A comparative assessment of different methods of angiography for diagnostics of echinococcosis of the liver is given. Conditions of prolonged contrast of vessels and parenchyma of the organ were created by splenoportography and arteriography of the liver with maiodyl which allows to determine the presence and degree of morphofunctional changes and spread of the pathological process in echinococcosis of the liver.

Contrast Media↗
PubMed1989

[Clinico-electroencephalographic correlations in the process of rehabilitation of patients with epilepsy].

A total of 50 patients with epilepsy underwent an electroencephalographic investigation at the rehabilitation stage during remission. EEG tests established that the discontinuation of epileptic seizures was followed by a stepwise compensatory EEG rearrangement. In patients that had had rare seizures, the EEG normalization was characteristic of the 2 to 3 years-long remissions. With frequent polymorphic seizures, the background activity was normalized in the steady remission of many (5 and more) years duration. The cessation of antiepileptic therapy should be effected under a mandatory EEG control. The absence of negative EEG changes on anticonvulsants discontinuation is a sign of correct treatment paradigm.

Anticonvulsants↗
PubMed1988

[Results and future of the activities of the Department of Medical Radiation Physics of the Central Scientific Research Roentgenoradiology Institute of the USSR Ministry of Public Health].

The main directions of research activities, pursued in the Department of Medical Radiation Physics over 25 years, are reviewed. The staff-members have done a lot for the development of Soviet modern radiotherapeutic engineering (electron accelerators). They are devising a cyclotron complex for purely medical purposes. Investigations in fundamental dosimetry, software for radiation therapy, computer use in x-ray studies will permit research in the following directions: --physicotechnical aspects of medical use of cyclotrons; --automation of radiation therapy technology (including software and control systems); --procedures to ensure quality in radiation therapy; --dosimetric maintenance of radiobiological experiments; --computer use for analysis of medical images.

Computer Systems↗