PubMed Health⌕ Search

Biomedical subjects

V A Oleĭnik

Publications and source records attributed to V A Oleĭnik.

At least 19 recordsLinked to original sources
PubMed1993

[The effect of the one-time and long-term administration of preparations acting on biogenic amine metabolism on the blood level of pressor peptide hormones].

Blood contents of pressor peptide hormones vasopressin and angiotonin II were studied in patients with neuro-endocrine syndrome before and after single intake and prolonged treatment with anti-serotonin drug peritol and cholinergic agent parlodel which affect biogenic amine metabolism and, consequently, influence blood pressure. Single doses of the drugs were established to cause different blood dynamics of vasopressin and angiotonin II which classified as marked and paradoxic reactions on peritol and parlodel used separately and associatively. Fall of blood vasopressin content induced by single dose of parlodel was accompanied by blood pressure decrease. Tree-week treatment with peritol and parlodel exerted hypotensive effect and significantly reduced vasopressin blood content.

Adolescent↗
PubMed1993

[Morphofunctional characteristics of malignant thyroid gland tumors in children from various regions of the Ukraine, who have been victims of of the Chernobyl nuclear power plant accident].

Thyroid cancers in children from the affected areas of Ukraine were investigated by means of light (33 cases) and electron (20 cases) microscopy. Statistical data from 25 regions of Ukraine have been analyzed concerning thyroid cancer in patients aged up to 18 years for the period 1981-1990. There is an increase in the number of thyroid cancers in the children of Ukraine from 0.04-0.06 cases in the "pre-chernobyl" period to 0.23 cases per 10(5) children's population in 1990. In the children operated in the Clinic of the Institute of Endocrinology in 1990-1991, severe forms of thyroid lesions with metastases to the lymph nodes were noted. Histopathological studies show prevalence of different variants of papillary cancer with presence of follicular, solid, poorly differentiated areas. Ultrastructural analysis revealed polymorphism of tumour cells, various degrees of their differentiation and functional specialization that point to a mixed multicomponent nature of carcinomas.

Accidents↗
PubMed1991

[Improvement of infusion-transfusion therapy in a multidisciplinary emergency care hospital].

The article deals with the analysis of works of S.S. Yudin's students and followers devoted to scientific practical and scientific-organizational research into optimization of infusion-transfusion therapy in emergency service hospitals in emergency states: multiple and combined trauma, the crush syndrome, burns, exogenous poisoning, and pyoseptic complications in surgical and traumatological practice. The principles of transfusion media rationing in an emergency service hospital, particularly in mass admission of patients and accident victims, are substantiated. The medico-economical efficacy of including infusion-transfusion therapy in complex treatment of emergency conditions is shown.

Blood Transfusion↗
PubMed1991

[Effect of pathogenetic treatment on vasopressin secretion in patients with hypothalamic syndrome].

Blood vasopressin concentration, hypothalamic response to stress resultant from insulin hypoglycemia and to acute furosemide load were measured in 72 patients with neuro-endocrine-metabolic form of hypothalamic syndrome. Pathogenetic treatment was decided upon by sensitivity to dopaminergic drug parlodel and antiserotonin drug peritol. According to the sensitivity tests the patients received either parlodel (5 mg/day) or peritol (12 mg/day) for 3-6 months. There were also patients on symptomatic treatment aimed at reduction of body weight. Peritol treatment promoted a decline in basal blood level of vasopressin and better response to insulin hypoglycemia and furosemide test. Parlodel treatment normalized vasopressin blood concentration and hypothalamic response to stimulators. Routine symptomatic therapy did not induce differences in vasopressin level compared to active stage of the disease.

Adolescent↗
PubMed1990

[Thyroid-stimulating immunoglobulins and the incidence of postoperative hypothyroidism in patients with diffuse toxic goiter].

Thyroid function was studied in 38 patients with diffuse thyroid goiter after subtotal thyroidectomy (3.82 and 25.9 months after surgery. Postoperative hypothyroidism developed less frequently in diffuse goiter patients who showed before treatment thyro-stimulating antibodies in the blood. The authors recommend a differential approach to the volume of thyroidectomy depending on the presence and absence of thyroid-stimulating antibodies before the operation.

Adolescent↗
PubMed1990

[The efficacy of treatment using expanded programs of megavolt irradiation and polychemotherapy in patients with lymphogranulomatosis in stages I, II and IIIA].

The authors relate the results of multimodality treatment of 90 patients with stages I-IIIA lymphogranulomatosis. The total survival amounted to 86.4 +/- 3.8% within the time exceeding 7 years. The efficacy of the treatment of patients with lymphogranulomatosis of different stages by using multi-beam and broad-beam radiation is under comparison. The data obtained indicate that total radiation of lymph nodes in patients with stage II lymphogranulomatosis is not advisable.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1990

[Optimal control of the microflora environment in suppurative foci].

The informative capacity of various statistic parameters characterizing the ecology of pathogens of purulent processes was studied. Many-years' results of the routine bacteriological tests of the materials from purulent wounds in patients from surgical, traumatological and burn departments served as the study subjects. The frequency, persistence and contamination capacity of the pathogens were investigated. Data on the changes in the frequency parameter with respect to the main pathogens of wound infections in various contingents of patients were collected. In relation to the observation period and contingent of the patients, various microorganisms were found to be permanent, supplementary and casual. The use of the ecological parameters was shown to provide integrated information on the etiological role of the pathogens in the development of purulent processes. The information characterized the microbial properties which should be considered in planning the use of antibacterial drugs and estimating the efficacy of the epidemiological control.

Abscess↗
PubMed1990

[Changes in the composition of the causative agents of wound infection in emergency surgery in the period from 1967 through 1987].

The composition of the causative agents of suppurations, isolated from suppurating wounds of patients hospitalized at different departments of the Sklifosovskiĭ Emergency Aid Institute was studied. The proportion of representatives of different microbial families among more than 18,000 strains of the causative agents of wound infection was estimated. Fluctuations in the amount and structure of the agents were analyzed in different clinics over the period of 1967-1987. Under the conditions of emergency aid hospital Staphylococcus aureus proved to be the most frequent causative agent of suppurative inflammatory processes at different departments. At the same time no tendency towards an increase of the etiological role of any microbial family in the development of wound infections was noted. The incidence of different causative agents of suppurations was found to vary at different departments, depending on their specialization and season. The results of observations on the composition of the causative agents of wound infection may be used for the planning and evaluation of antiepidemic measures.

Bacteria↗
PubMed1989

[The renin-angiotensin-aldosterone system in hypertension of hypothalamic origin].

The results of the study of angiotensin-II and aldosterone++ concentrations, renin activity in blood plasma, the response of adrenal cortex glomeruli and juxtaglomerular system to insulin hypoglycemia, metoclopramide++, furosemide and exercise were considered for 119 patients with neuroendocrine form of hypothalamus syndrome. It was found that hypothalamic regulation of renin-angiotensin-aldosterone++ system underwent changes. Hypersecretion+ of aldosterone++ is an important factor in pathogenesis of arterial hypertension in hypothalamic syndrome.

Adolescent↗
PubMed1988

[Several aspects of the pathogenesis of disturbances of hemostasis in patients with diffuse toxic goiter].

Components of the kallikrein-kinin system of the blood and some hemostatic indices were studied in parallel in 32 patients with diffuse toxic goiter. A decrease in the levels of prekallikrein, kininogen, the activity of kallikrein and kininase inhibitors in the blood plasma of the examinees resulted in raised activity of the kallikrein-kinin system in decompensated thyrotoxicosis. Hemostatic changes were characterized by signs of chronic disseminated intravascular coagulation. It was shown that kinin formation and blood coagulation were correlated. A certain parallelism in the increment of the activity of the kinin system and disorders of hemocoagulation was noted with an increase in a degree of severity of thyrotoxicosis. A tendency to improved indices was also noted after thyrostatic therapy.

Adolescent↗