Sounding board. A health-care system for the elderly.
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Biomedical subjects
Publications and source records attributed to V A Portnoi.
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The case reported here and others like it indicate that thyrotoxicosis can be manifested by psychosis or bizarre neurologic signs. Thus, hyperthyroidism in late life may be overlooked and the patient given the diagnosis of psychosis secondary to organic brain syndrome or cerebrovascular accident. Thyrotoxicosis, which is treatable, should be looked for as a possible cause of deterioration of mental function with or without focal neurologic signs.
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Case histories of four elderly patients with central nervous system signs of digitalis toxicity were reviewed. Evidence of toxicity included lethargy, depression which was not present previously, confusion, restlessness, emotional instability, hyperventilation, and vertigo. Vomiting developed four days after the onset of the mental changes. No cardiac arrhythmias were observed. Digoxin serum levels ranged between 4.2 and 7.0 ng/ml. Serum potassium values were within normal limits. Three of the four patients recovered with a return of their mental status to the pretoxic state. The fourth case was fatal. At autopsy long-standing myocardial ischemia was the only significant finding.