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Biomedical subjects

V A Pshenichnov

Publications and source records attributed to V A Pshenichnov.

At least 19 recordsLinked to original sources
PubMed1991

[The pathogenesis of Q fever in the intratracheal infection of guinea pigs].

The intratracheal introduction of R. burnetii is the method of infection, highly similar to aerogenic infection, the most widespread route of R. burnetii infection in humans under natural conditions. This suggests that the study of the pathogenesis of Q fever resulting from the intratracheal infection of guinea pigs is highly topical. The authors have established that after the penetration of the infective agent generalized infection develops in the animals with rickettsiae accumulating mostly in the lungs and the organs of the reticuloendothelial system being affected; this infection is commonly more pronounced than that developing after the intraperitoneal inoculation of rickettsiae.

Animals↗
PubMed1988

[Immunoenzyme analysis in a system of serologic evaluation of louse-borne typhus vaccines].

The blood sera of persons immunized with different typhus vaccines have been studied in the complement fixation test, the indirect hemagglutination test and the enzyme immunoassay. The data thus obtained indicate that the enzyme immunoassay is highly sensitive and can be universally used for the determination of antibodies to Rickettsia prowazekii after primary and booster immunization with different typhus vaccines. This method detects specific antibodies both at an early period and, which is of particular importance, at a remote period after immunization (3 years later) when complement-binding and hemagglutinating antibodies are absent. This is seemingly indicative of the two-phase character of postvaccinal immunity induced by live typhus vaccine.

Antibodies, Bacterial↗
PubMed1985

[Reaction of the biologically active points of the skin to immunization with typhus vaccine].

Electroacupuncture diagnosis was used to demonstrate the reaction of biologically active points of the skin (BAPS) to immunization with typhus vaccine. In 7 persons immunized with chemical and live (strain E) typhus vaccines, the reaction differed significantly from the initial parameters and other measurement data obtained in a group of unvaccinated subjects. The reaction of the BAPS was noticeable starting from the first day after vaccination and was far ahead of seroimmune shifts detectable in the host. The best correlation was established between the seroimmune response and the activity of the acupuncture points on meridians X and I (a positive correlation) and on meridians III, VIII and XI (a negative correlation).

Acupuncture Therapy↗
PubMedDate not supplied

[An experimental study of the contact transmission of the Marburg virus].

Experiments in guinea pigs and M. rhesus monkeys showed the possibility of contact infection of animals with Marburg virus. Secondary infection occurred most intensively when the monkeys were kept together but was also shown to be possible when the animals were separated but placed in the direction of the air flow from the sick monkeys as well as by "nose-to-nose" contact excluding the alimentary mode of transmission and the role of the agent excreted in the urine.

Aerosols↗
PubMedDate not supplied

[The therapeutic efficacy of ribamidil and virazole in experimental Lassa fever in monkeys].

The therapeutic efficacy of ribamydil and virasol was evaluated in experimental Lassa fever in monkeys which received these drugs at various intervals after the onset of the clinical illness. Ribamydil or virasol administered in the first day of fever protected from death 60% to 66% of the infected animals, but when the drugs were given 2 days after the onset of fever the number of survivors declined to 0.20%. When the treatment was started 4 days after the onset of fever none of the drugs prevented deaths of Lassa virus-infected baboons.

Animals↗
PubMedDate not supplied

[Experimental Lassa fever in hamadryas baboons].

Intramuscular or aerogenic inoculation of baboons with Lassa virus reproduced a severe form of the disease which clinically, pathoanatomically and virologically resembles the severe form of human Lassa fever reported in the literature. The severity of monkey infection is demonstrated by rapid development of symptoms of general toxicity in the presence of fever, manifestations of hemorrhagic diathesis, high level of viremia and isolation of the causative agent from nasopharyngeal washings.

Animals↗
PubMedDate not supplied

[The antiviral efficacy of ribamidil in an experimental infection of animals with the Venezuelan equine encephalomyelitis virus].

Considerable differences in antiviral efficacy of ribamydil were demonstrated in various animals experimentally infected with Venezuelan equine encephalomyelitis virus. The infection in baboons was quite similar to the manifestations of this disease in man as reported in the literature. With ribamydil used prophylactically, manifestations of the infection in monkeys were less marked.

Animals↗