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Biomedical subjects

V A Safonov

Publications and source records attributed to V A Safonov.

At least 19 recordsLinked to original sources
PubMed2005

Effect of opioids on mechanoreflexive respiration control.

The effects of opioids (morphine and fentanyl) on the function of mechanoreceptive respiration regulatory loop were demonstrated. In most opioid-treated rats (74% cases) vagotomy was followed by apneustic respiration with inspiration pause. Excess of opioids in rat CNS produced minor disturbances in the respiration rhythm, but in the absence afferent input from the mechanoreceptors of respiratory pathways and lungs, pronounced periodic apneustic respiration with inspiration pauses developed. The opioidergic system is involved in the formation of respiratory rhythm, but had no appreciable effect on transmission of mechanoreceptive nerve pulses from respiratory pathways and the lungs to the respiratory center.

Analgesics, Opioid↗
PubMed2004

[Computed tomography in the diagnosis of pulmonary thromboembolism].

To verify the hypothetical diagnosis of pulmonary thromboembolism (RTE), 64 patients were provided CT of the chest organs with pulmonary artery opacification, Twenty-seven patients had thromboemboli in different parts of the vascular tree. In 9 patients, the thromboemboli were parietal, with flow preservation at the site of thromboembolus fixation, and in 18 patients, the emboli occluded the vascular lumen. In 11 patients with occlusion of the segmental and subsegmental arteries, the clinical course of RTE, in addition to acute cardiovascular insufficiency, was marked by cough, hemoptysis and pneumoinfarction; the tomograms showed well-defined parts of pneumoinfarction and pleural exudate. In the event of non-occlusion thromboembolism, the clinical picture was only marked by acute cardiovascular insufficiency. In 37 patients, no thromboemboli were discovered in the system of the pulmonary artery. Of these, 27 patients presented, however, with some other pathology of the chest organs.

Humans↗
PubMed1998

[Comparative analysis of changes in respiration and systemic hemodynamics during activation of GABA receptors in cats and rats].

Effects of alpha-hydroxybutyrate (GHB) involved a decrease in the respiration rate and subsequent periodic breathing in anesthetised cats and rats. No considerable changes occurred in systemic circulation. There were, however, some differences between the species in the patterns of respiratory arrest. Possible mechanisms of the similarity and difference are discussed.

Animals↗
PubMed1993

[The participation of the GABAergic system of the brain in shaping the breathing rhythm].

I.v. administration of sodium hydroxybutyrate induced periodic apneustic breathing with inspiratory arrests in anesthetised cats. Bilateral vagotomy did not change respiratory or circulatory parameters under these conditions. Administration of the same agent into both nuclei tractus solitarii induced similar effects, as well as administration of the GABA agonist baclofen. The data obtained suggest that the medullary GABA-ergic system takes an active part in generation of the respiration rhythm.

Animals↗