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Biomedical subjects

V A Samsonov

Publications and source records attributed to V A Samsonov.

At least 73 records · Page 4Linked to original sources

[Complications and causes of fatal outcomes in prostatic cancer].

An analysis of post-mortem examination data on 600 cases of cancer of the prostate showed that among the most frequent complications were ascending pyelonephritis (51.7%), focal pneumonia (42.8%) and cachexia (36.7%). Deaths were caused mainly by progression of cachexia (24.3%), uremia (24.3%) and focal pneumonia (19.5%). Only a small percentage of patients died from postoperative complications and concomitant pathology.

Adenocarcinoma↗

[Clinico-morphological characteristics of transitional cell carcinoma of the prostate].

Transitional cell carcinoma was identified in 11 out of 600 autopsied cases of prostatic cancer (1.8%). Invasion into adjacent organs and tissues was recorded in 6 out of 11 cases, metastases--in 9 (bone lesions--5 cases). Most of the cases suffered poorly-differentiated transitional cell carcinoma (areas of undifferentiated small-cell tumor in some cases). Transitional cell carcinoma of the prostate is a highly malignant tumor, resistant to hormonal and radiation treatment.

Aged↗

[Fibroma of the small intestine with heterotopia of the pyloric glands in the mucous membrane covering the tumor].

Small bowel tumour, 5 X 3 X X 3 cm in size, in a woman of 52 provoked intestinal invagination. Small bowel was resected with the tumour which was diagnosed histologically as a soft fibroma. Focal areas of the pyloric glands with single argyrophil endocrine cells as well as "stomach metaplasia" of the epithelium of one crypt were detected in the intestinal mucous membrane covering tumour. In the author's opinion, this heterotopia is related to the developmental malformation.

Choristoma↗

[Metastases of prostatic cancer].

Among 600 necropsy cases of prostatic carcinoma metastases were found in 425 (70,8%). Solitary metastasis was found in 11 cases only, in the rest multiple metastases were observed. The most frequent site of metastases were lymph nodes (42,7%), bone (29,6%), liver (19,8%), lungs (14,5%), pleura (9,2%). Bone metastases were most frequently osteoplastic, localized mainly in the vertebral column (19,7% of all carcinomas), pelvic bones (8,5%), ribs (8,5%). In 4 out of 118 cases of metastases to the vertebral column, a pathologic fracture was observed, this being much rarer than in metastases of a clear-cell carcinoma of the kidney (11,1%) when metastases are generally osteolytic.

Bone Neoplasms↗

[Nodular hyperplasia of the prostate with focal changes of the phyllode type].

Histological examination of the prostatic nodes enucleated in 364 patients because of nodular hyperplasia revealed in 2 cases focal changes resembling a phyllode hyperplasia of the mammary gland. The third case exhibited a fibro-epithelial papilla with an intensive fibroblast proliferation protruding into the lumen of the gland with a cystic dilatation. It is suggested that the above changes may become an initial stage of the phyllode type focal hyperplasia.

Aged↗

[Prostatic squamous cell cancer and its differential diagnostic contrast with squamous cell metaplasia].

Thirteen (2.2%) squamous-cell carcinomas were found among 600 autopsy cases of prostatic carcinoma. In the surgical material squamous-cell carcinoma was observed in 3 cases (1.7%). Clinical and morphological analysis of these 16 cases together with the published observations shows squamous-cell carcinoma of the prostate to have a grave clinical course and bad prognosis. One observation of the erroneous histologic diagnosis of carcinoma in case of squamous-cell duct and gland metaplasia of the prostate is reported. The differential-diagnostic differences between dyshormonal squamous-cell metaplasia and squamous-cell carcinoma of the prostate are described.

Adenocarcinoma↗

[Dimorphic (transitional-anaplastic) ductal cancer of the prostate].

Prostatic carcinoma of a specific structure with widespread metastasis in a 7 year-old patient who was treated with oestrogens and survived more than 4 years after the appearance of the first symptoms is described. Histologically in the primary tumour the combination of highly differentiated transitional-cell carcinoma (without cell degeneration and necrosis) and anaplastic, mainly small-cell carcinoma is found in the prostatic ducts. Pronounced degenerative and necrotic changes similar to those resulting from the oestrogen therapy with a positive effect are observed in the anaplastic carcinoma. Metastases had a structure of transitional-cell carcinoma.

Aged↗

[So-called endometrial carcinoma of the male prostatic utricle].

From a review of the literature the author concludes that the histogenesis of the so-called endometrial carcinoma of the male prostatic utricle first described by Melicow and Pachter in 1967 is not completely clear yet. It may be assumed that tumors of a similar histological structure may be of different histogenesis, utricular and ductal, and that there are fine structural, histochemical, and histoenzymological differences between them which have not yet been studied sufficiently. It is suggested that the use of the immunoperoxidase method may be promising in such studies.

Aged↗

[Thromboembolism and tumor embolism of the pulmonary artery as a cause of death in oncourologic diseases].

The autopsy material of pathological departments of Leningrad and Petrozavodsk for 1953-1980 was studied. Thromboembolism of the pulmonary artery was found to be the cause of death in renal carcinoma in 19 (1.5%) cases out of 1248 fatalities due to this carcinoma, in carcinoma of the renal pelvis and ureter in 1 (1.3%) out of 75, in urinary bladder carcinoma in 14 (1.5%) out of 918, in prostate gland carcinoma in 17 (2.8%) out of 600 cases. The source of thromboembolus in renal carcinoma and renal pelvis carcinoma most frequently was a thrombus of the lower vena cava, in the urinary bladder carcinoma that of femoral veins, in prostate gland carcinoma that of the small pelvis veins. Among the causes of death in renal carcinoma, tumor embolism of the pulmonary artery was observed in 7 (0.6%) cases.

Adult↗

[Primary lymphosarcoma of the prostate gland].

Two large tumor nodes of a total weight of about 100 g were removed from the prostate gland of a patient of 28 with the duration of the disease symptoms of approximately 3 1/2 months. Histological diagnosis of polymorphocellular sarcoma was made. On the 19th day postoperation the patient died with phlegmon of the small pelvis tissues in the presence of cachexia. The autopsy revealed a tumor of the prostate gland outgrowing into the soft tissues of the small pelvis without metastases. Histologically it was a diffuse prolymphocytic lymphosarcoma of the prostate gland with small-loop argirophilic reticulum. This neoplasia was combined with multiple glandular gastric polyps.

Adult↗

[Pathologicoanatomic data on metastasis of the stomach cancer to the ovaries].

The results of evaluation of the data on autopsies for stomach cancer provided by the pathology departments of the hospitals of Leningrad (1975-1979) and Petrozavodsk (1965-1979) are presented. Metastases into ovaries were found in 98 cases. i.e. 3.5% of the total number of autopsies which revealed stomach cancer (2,823) and 7.4% of the autopsies performed in patients who died from stomach cancer (1,320). The rates of incidence of gastric cancer metastases into ovaries appeared to be nearly half those reported for Leningrad hospitals for the previous period (1952-1969) by S. I. Kulinich. Moreover, mortality rates for cases of metastases into ovaries tend to increase considerably in the older age groups: deaths at the age of 50 and older (up to 97 years) amounted to 73.5% of cases. The said alterations are regarded as a manifestation of pathomorphism of stomach cancer.

Adult↗

[Association of prostatic adenocarcinoma with transitional cell and squamous cell carcinomas of the same organ].

Among 13 cases of transitional cell carcinoma of the prostate there was one case of its combination with clear cell adenocarcinoma of the same organ. Areas with trend to glandular metaplasia were found in transitional cell carcinoma. Also, a very rare case of combination of prostate adenocarcinoma and squamous cell keratinizing microcarcinoma of the excretory duct of the organ is described. In both cases there were foci of dysplastic lesions of both glands of the prostate (atypic hyperplasia) and epithelium of its ducts (squamous cell metaplasia with areas of hyperplasia of basal and parabasal cells).

Adenocarcinoma↗