Biomedical subjects
Publications and source records attributed to V A Simonenkova.
The interrelations between lymphocytes and intestinal epithelium cells after total X-ray irradiation (15 Gy) were investigated autoradiographically in CBA mice. The labelled lymphocytes injected in the irradiated animals migrated in intestinal epithelium, the label being present within vacuoles of the crypt cells and later in their nuclei. The trophic function of lymphocytes and the nature of the so-called apoptosis are discussed.
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A histochemical method is described for localizing xanthine oxidase--the key enzyme in the purine catabolic pathway. The above method is based on the reduction of p-Nitroblue tetrazolium during hypoxanthine enzymatic oxidation, phenazine methosulfate being an intermediate electron acceptor. The patterns of the reaction product distribution suggest that the Kupffer cells and the sinusoidal endothelium possess the highest xanthine oxidase activity.
Morphological pattern of the retina in the trauma focus and outside its borders has been studied electron microscopically after application of ruby laser monoimpulse radiation (wave length 0.69 mcm, energy 1.06-1.25 X 10(-4) J and impulse length 20 nc). The trauma focus is not limited only by the volcano-shaped inflation of the retina. The lesion of the photoreceptory ultrastructure and the disturbance of microcirculation in the vascular layer are defined in 3 zones investigated: at the distance 50, 100 and 1,000 mcm from the spot on the retina, visible in the light microscope. This phenomenon should be taken into consideration when choosing therapeutic doses of laser radiation, applied for treatment of various diseases of the eye.
The ultrastructure of the aero-hematic barrier (AHB) of the lungs has been studied in the mostly used laboratory animals-mice and rats. In 2 clinically sound animals in macroscopically unchanged parts of the lungs certain disorders of rheological blood properties have been revealed, edema and focal destruction of endotheliocytes and alveolocytes of the I type, local destruction of the thin part of AHB. The changes revealed in AHB ultrastructure in intact mice and rats are in many respects similar to those developing in the lungs under various extreme influences. Therefore, a wide and thorough investigation of the lung structure in intact animals makes it possible to avoid erroneous conclusions at examining various pulmonary pathology and contributes to a correct estimation of its manifestation degree.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.