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Biomedical subjects

V A Trufakin

Publications and source records attributed to V A Trufakin.

62 records · Page 4Linked to original sources
PubMedDate not supplied

Changes in various measures of immune status in mice subject to chronic social conflict.

Levels of the major regulatory subpopulations of lymphocytes in the thymus and spleen and blood lymphocyte dehydrogenase levels were measured in male mice with aggressive and submissive patterns of behavior formed over 10 or 20 aggressive confrontations leading to repeated experience of victory or defeat. The results showed that repeated experience of social confrontation non-specifically increased the proportion of segmented neutrophils and lactate dehydrogenase activity in both participants in aggressive encounters, and decreased the numbers of CD4+ and CD8+ T-lymphocytes in the spleen. Succinate dehydrogenase specifically decreased in the lymphocytes of aggressive mice and increased in the lymphocytes of submissive mice. The proportion of CD4+ T-lymphocytes in victims' thymuses also decreased. Changes in metabolic measures and percentage ratios of lymphocyte contents were dynamic and depended on the duration of confrontational interactions.

Aggression↗
PubMedDate not supplied

[Effect of the enteric sorbent noolit on the psychoemotional status in mice].

The enterosorbent noolit (representing a mineral matrix base with immobilized lithium and silicon compounds) significantly affects the psychoemotional state of mice with depression model induced by prolonged social emotional stress. Noolit administration produces a pronounced anxiolytic and antidepressant effect and reduced the level of behavioral deficiency in the test animals.

Animals↗
PubMedDate not supplied

[Modulation of the circadian rhythm of the glucocorticoid hormone level in mice by thymoptin administration at various times of day].

A study was made of the level of corticosterone in mouse blood plasma after 4-time daily administration of thymopthin (a drug containing 1% of thymosin-alpha 1, synthesized in the All-Union Research Institute of Technology of Blood Substitution and Hormonal Drugs) at a doze of 0.05 mg per mouse in the morning and evening. The object of investigation was blood plasma of CBA male mice aged 12-16 weeks. The investigation was experimental. The purpose was to elucidate a possible role of thymic hormones in the regulation of circadian rhythm of glucocorticoid function of the adrenal cortex. Plasma concentration of corticosterone was determined by concurrent protein binding of hormones. Thymopthin administration was shown to result in change of circadian rhythm of the level of corticosteroids in mouse plasma. Drug administration in the morning elevated daily concentration of corticosterone, that also evening reduced it as compared to the control group that in the received the same volume of physiological salt solution. A curve of the daily time course was obtained as a result of smoothing by a method of the least squares. These results should be taken into account when using thymic drugs for therapeutic and experimental purposes.

Adrenal Glands↗
PubMedDate not supplied

[Biorhythms of the lymphoid system and possibilities of immunomodulating chronotherapy].

The paper provides the authors' own data and the data available in the literature concerning diurnal rhythms of immunological parameters in the development of experimental immunopathological conditions. Desynchronizing these rhythms, a change in the light regime is shown to accelerate the time course of the development of an autoimmune process in mice. The potentialities of chronotherapy of experimental immunodeficiencies with thymic preparations have been studied. It is emphasized that chronobiological studies are particularly essential in solving the biomedical problems of the Far North with its extreme conditions and a great deal of desynchronizing factors.

Adjuvants, Immunologic↗
PubMedDate not supplied

Thymus morphology in NZB mice after multiple dosage with somatotropin.

Cortical matter increased in the thymus after ten-day dosage of Coombs-positive NZB mice with somatotropin and thyroxine; cortical matter predominated over medullar matter. Secondary lymphoid follicles disappeared and the number of mast and plasma cells decreased. With administration of the hormone, rosette-forming cells began to appear in the thymus.

Animals↗