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Biomedical subjects

V A Znamenskiĭ

Publications and source records attributed to V A Znamenskiĭ.

At least 19 recordsLinked to original sources
PubMed1998

[Anaerobic-aerobic infection in acute appendicitis].

362 patients with acute appendicitis (AA) were examined. For microbiological diagnosis of aerobic and anaerobic nonclostridial microflora we used complex accelerated methods (including evaluation of gram-negative microorganisms in comparison with tinctorial-fermentative method of differential staining according to oxygen sensitivity of catalasopositive together with aerobic and cathalasonegative anaerobic microorganisms) as well as complete bacteriologic examination with determination of sensitivity of the above microorganism to antimicrobial remedies. High rate of aerobic-anaerobic microbial associations and substantial identity of microflora from appendicis and exudate from abdominal cavity was revealed, which evidenced the leading role of endogenous microorganisms in etiology and pathogenesis of AA and peritonitis i. e. autoinfection. In patients with destructive forms of AA, complicated by peritonitis it is recommended to use the accelerated method of examination of pathologic material as well as the complete scheme of examination with the identification of the isolated microorganisms and the correction of antibiotic treatment.

Abdomen↗
PubMed1991

[An electron microscopic study of the interaction of bacterial intestinal microflora and rotavirus virions].

Transmission electron microscopy has revealed the capacity of rotaviruses for adsorption on Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis cells and the absence of such capacity with respect to Enterococcus faecalis, Lactobacillus casei and Edwardsiella tarda. Different degrees and a varying character of the adsorption of rotaviruses by the representatives of the opportunistic group of bacteria have been established, which may aggravate the course of rotavirus diarrhea due to the aggregation of viral particles. For the first time the phenomenon of the selective destructive adsorption of rotaviruses by E. coli indigenous strains M-17 and 33/29, typical representatives of normal enteric microflora, is described. This observation should be regarded as one of important biological mechanisms responsible for the protection of the body from rotavirus infection.

Adsorption↗
PubMed1991

[The adhesion of pathogenic microflora on carbon sorbents].

The adsorbing activity of granulated carbonic sorbents SKN and KAU, as well as their oxidated forms, containing protogenic carboxylic and phenolic groups with respect to Shigella flexneri, Salmonella typhimurium, Escherichia coli, Streptococcus aureus and Pseudomonas aeruginosa pathogenic strains has been studied. As shown in this study, the process of interaction between microorganisms and carbonic sorbents has two stages. At the first stage the main role is played by long-distance electrostatic forces and at the second stage, by Van der Waals short-distance forces, as well as bonds formed between cell structures and surface groupings of carbonaceous materials. In the mechanism of interaction between microbial cells and carbons the geometry of carbon surface plays an important role. KAU(0)-1 exhibits the highest degree of adhesion with respect to pathogenic bacteria.

Adsorption↗
PubMed1989

[Sensitivity of Pseudomonas bacteria to iodopiron and dimexide determined by electron microscopy].

A structure of the pyocyanic bacterium culture was studied by the method of electron microscopy of native preparations and ultrafine sections of the cells, which contained in the quantity of 10(5)/ml of suspension, and were treated with iodopiron in the concentration of 93.75 mg/ml, 10% dimexide solution and their combination. The increase in damaging effect on bacteria of the combined use of chemopreparations permits to recommend their complex administration in local pyocyanic infection in burned patients.

Anti-Bacterial Agents↗
PubMed1988

[Study of general toxic properties and side effects of polymethylsiloxane and gentamicin immobilized on it].

A long-acting dosage form for local use of gentamicin immobilized on polymethylsiloxane, a silicon organic adsorbent was developed. It combined the antimicrobial spectrum of gentamicin and the local sorption-detoxication action of the matrix. In acute and chronic experiments on 5 species of laboratory animals it was shown that polymethylsiloxane had no general toxic action on the animals, no damaging action on their internal organs, did not affect their functions and the state of the biological fluids, had no pyrogenic or allergenic effect. During gentamicin immobilization on polymethylsiloxane there was observed no increase in the antibiotic toxicity as compared to the nonimmobilized dosage form of the antibiotic. Further study of the immobilized dosage form of gentamicin is advisable.

Animals↗