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Biomedical subjects

V A Zuev

Publications and source records attributed to V A Zuev.

At least 19 recordsLinked to original sources
PubMed2003

Artificial aging of mice.

Clinical signs of aging verified by morphometrical analysis of brain tissue were observed in young mice 4 months after administration of brain extract from old mice (5 intraperitoneal injections).

Aging↗
PubMed2001

[From prion diseases to the problem of aging and death].

The brain tissue of aging mice shows a factor that stimulates the proliferation of cells of glial origin both in primarily trypsinized and inoculated cultures. This factor that is likely to be of peptide origin is characterized by pronounced accumulation dynamics with increasing age in mammals, by unusually high thermal stability and by its possible detection in the brain extracts by means of isoelectrofocusing rather than electrophoresis. The author proposes a concept under which the brain tissue of aging mammals, including human beings, accumulates the factor that is active in stimulating the proliferation of glial elements, thus resulting in impairment of neuronal trophism, which can in turn be a cause of their death and, in the long run, a cause of death of the brain and the whole body.

Aging↗
PubMed1990

[The use of T-activin for the prevention of congenital influenzal infection in mice and the correction of the immune deficiency].

Viremia accompanying influenza infection and the possibility of transplacental passage of the virus into the fetus make it expedient to develop measures for the prophylaxis of intrauterine infection of the fetus in case of influenza during pregnancy. The work presents the optimum scheme of administration of T-activin for prophylactic purposes to pregnant mice with acute influenza infection. Besides, the use of T-activin for immunocorrection in case of established congenital influenza infection in mice is proposed.

Adjuvants, Immunologic↗
PubMed1990

[Characteristics of the damage to immunocompetent organs in experimental slow influenza infection].

Morphological changes in immunocompetent organs were studied in 30 mice with slow influenza infection. Histological, histochemical, and electron microscopy studies revealed destructive changes in different cell populations of the thymus and spleen. The changes were more pronounced in the reticuloendothelial cells of the thymus and endothelium of thymic capillaries. Complex examination helps to outline the general pathological patterns in interpreting the pathogenesis of experimental slow influenza infection.

Animals↗
PubMed1989

Influenza virus genetic sequences in the blood of children with congenital pathology of the CNS.

Influenza A virus genetic sequences revealed by dot hybridization were detected in peripheral blood cells, serum and liquor of three children with congenital pathology of the CNS. The children were born to mothers who contacted influenza during pregnancy. The virus-specific sequences were found for a long period of time (83 days in one case). The serum of the child did not contain antibodies against M protein suggesting that viral nucleocapsids but not the virus particles persist in the organism of the sick child.

Central Nervous System Diseases↗
PubMed1984

[Cochleovestibular disorders in chronic alcoholics].

Auditory and vestibular functions were studied in 85 chronic alcoholics (45 subjects with Stage II and 40 with Stage III alcoholism). In 54.1% of all cases, disorders in the auditory analyzer, predominantly at the site of the first neuron, were detected. It was revealed that following the progression of the disease to Stage III, auditory disturbances in such patients became more frequent and prominent. The study of the vestibular analyzer showed that the hyperreflexia of caloric and postrotatory nystagmus characteristic of the second stage of chronic alcoholism was replaced, at the next stage of disease, by normo- and hyporeflexia; there was also an increase in the changes of caloric nystagmus expressed in the form of rhythm disturbances.

Adolescent↗