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Biomedical subjects

V Adrian

Publications and source records attributed to V Adrian.

9 recordsLinked to original sources
PubMed1999

[Synthesis, antimicrobial effects and adverse effects of new structures of urea, hydrogen peroxide and tensides].

A substantial extension of the applicability of hydrogen peroxide will be reached by using occlusion compounds of anionic, amphoteric (dipolar ionic), cationic, nonionic, or polyfunctional tensides with hydrogen peroxide in urea. Occlusion compounds with 3 as well as with 4 components containing natural equivalent and antimicrobial effective tensides were synthesized and tested. By synthesis in an anhydrous system the content of active substances as well as the mixture ratio of the components may be adapted to the conditions necessary according to the appropriate purpose. Occlusion compounds are characterized by a broad and well-balanced spectrum of antimicrobial effectivity. Concentrations in the range of 0.1 to 0.4% are practicable to preserve pharmaceutical preparations or technical products, respectively. Several compounds show a sporicidal activity in concentrations between 0.3 and 0.6% and, with an appropriate action time (> 24 h) also a moderate effectivity against polioviruses. In the conventional cell culture, in the perfusion cell culture, and in the phytotoxicity test using cress seed, respectively, low biological activity of the occlusion compounds was found.

Anti-Bacterial Agents↗
PubMed1998

[Explant test with skin and peritoneum of the neonatal rat as a predictive test of tolerance of local anti-infective agents in wounds and body cavities].

In vitro culture of peritoneal explants of neonatal rats after previous application of agents simulating wound antisepsis is a sensitive screening method for the determination of the tissue compatibility of local wound antiinfectives. Two test models are differentiated: (1) separated peritoneal explants as a model for chronic or deep wounds and (2) peritoneum in situ in the experimental animal with subsequent extraction and cultivation of the explants. Considering the present state of knowledge the following conclusions can be drawn regarding antisepsis of wounds: Lavasept (0.1%) may be classified as the agent of choice for deep and chronic wounds, for drip-suck irrigation and for antiinfective lavage of body cavities inclusively for peritoneal lavage (0.05%). Taurolidin is antiseptically effective in long term application (> 6 h), and because of its antitoxic effect as well as lack of cytotoxicity it is especially suitable for peritoneal lavage. Betaisodona solution is very well suited for superficial contaminated wounds and can be used in a dilution of 1:10 for short-term rinsing of deep wounds, including body cavities but not for peritoneal lavage. Ethanol causes no inhibition of explant growth and therefore retains its importance in wound antisepsis.

Administration, Topical↗
PubMed1990

[The importance of the endogenous agent and environmental factor thiocyanate for nonspecific and specific resistance from the hygienic viewpoint].

Thiocyanate (previous designation rhodanide, SCN-) is a physiological substance which is ubiquitously spread in the animate nature. As an essential constituent of cell it participates in important physiological resp. biochemical processes. From the hygienic and microbiological point of view the occurrence of SCN- as environmental factor, its alimentary significance and its vitalizing effect (stimulation of nonspecific and specific warding off, stimulation of proliferation, protective effect at toxic loading) are of interest for the fundamental and applied research.

Animals↗
PubMed1989

[Mutagenicity testing in the sperm head test/mouse and mutagenic potency of 2 disinfectants on the basis of peracetic acid and phenols, respectively].

For the improvement of the registration of data by assessment of mutagenic risk the analysis of sperm-head abnormalities have been rendered as a suitable at indirect evidence of mutagenic potency. The reproduction of the results is well. The sensitivity of the test is high. The quantitative evaluation of genotoxic effects is possible. By reason of comparatively low methodical expense the screening investigations of species mouse are suitable, before more expensive tests will be accomplished for the elucidation of the mutation type. At 35 day-long intraperitoneal application the double number of sperm head abnormalities was approximately induced through Wofasteril (dose refer to main agent peracetic acid 2.6 mg/kg bw/d) and about 1/3 through cyclophosphamide (dose 25 mg/kg bw/d). With a 50% reduction of Wofasteril dose the mutagenic threshold-concentration was too low. The phenolic disinfectant Wofasept caused only slight no significant increase of the rate of sperm-head abnormalities (doses refer to the content of compounds, for Chlorocresol 1.6 mg/kg bw/d, for Clorofen 0.7 mg/kg bw/d and for detergent 4.8 mg/kg bw/d).

Acetates↗