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Biomedical subjects

V Alexander

Publications and source records attributed to V Alexander.

26 records · Page 2Linked to original sources
PubMed1978

Controlled substances registration for nonlicensed physicians.

Changes in drug laws and the addition of many formerly uncontrolled drugs to the controlled substances list has caused some concern about the registration of nonlicensed physicians. The question is, how does the recent medical school graduate obtain authorization to use the controlled substances he may need in the course of his postgraduate training at the hospital? The University of Alabama Hospitals, Birmingham, have answered the question with an effective system for hospital registration of nonlicensed physicians.

Alabama↗
PubMed1976

The selection of virus-resistant Chinese hamster ovary cells.

We have selected Chinese hamster ovary (CHO) cells resistant to infection by encephalomycarditis (EMC) virus. Thus far, we have obtained five lines resistant to EMC, all of which manifest different phenotypes. Three of the five are not persistently infected with virus, while two lines produce infectious virus and grow in its presence. The nonpersistently infected lines exhibit different resistance profiles to the other viruses we have tested, and they are stable in nonselective growth conditions. Their resistance appears to be due to a genetic alteration in the cell.

Cell Division↗
PubMed1976

Persistent reovirus infection of CHO cells resulting in virus resistance.

We obtained a persistently infected line of Chinese hamster ovary cells by selection for resistance to reovirus infection. The cells were persistently infected by a population of viruses that were (i) cytopathic for parental chinese hamster ovary cells and (ii) similar to wild-type reovirus in molecular characteristics. The growth rate, plating efficiency, and morphology of the cells were altered. A large majority of the cells in the population were infected. There was no detectable interferon present in the medium. The cells were relatively resistant to a wide range of viruses.

Animals↗
PubMedDate not supplied

Reappraisal of brain tumor risk among U.S. nuclear workers: a 10-year review.

A review of cohort mortality studies among workers exposed to ionizing radiation in U.S. nuclear programs was published in this journal 10 years ago. The present review extends that investigation to include four new groups of workers at Fernald (Ohio), Rocketdyne/Atomics International (California), Mallinckrodt Chemical (Missouri), and Los Alamos National Laboratory (New Mexico). The total number of brain tumors has doubled to nearly 300, with 3.8 million person-years of observation among 140,000 U.S. white male workers. This increased risk of brain tumor is highly consistent, persistent, and stable. The sum total of these studies dwarfs the reported experience of any other comparison group. The observed increased brain tumor risk is statistically significant and has changed little since 1991 when it was estimated at 15%. Study results from 1999 and 2000 may suggest a modest growing risk of 25-30%.

Brain Neoplasms↗
PubMedDate not supplied

Brain tumor risk among United States nuclear workers.

This review of ten carefully conducted cohort mortality studies of U.S. workers in the nuclear industry published during the past decade finds a significantly increased brain cancer risk. There is a high degree of consistency between these studies, as eight out of ten cohorts, individually, show comparable increased risks. A sensitivity analysis that selects the studies of highest quality yields similar increased risk estimates from brain cancer, no matter how the studies are grouped. Those index studies that provide radiation dose exposure information show stable excess brain cancer risks of 15% at cumulative doses of less than 5 rem. There are no obvious environmental or geographical confounders likely to explain this consistently observed excess brain cancer risk. Occupational chemical exposures may contribute to this excess brain cancer risk among nuclear workers, but the only apparent common factor in ten cohorts with quite diverse work environments is the potential for exposure to ionizing radiation. Overall, these index studies of more than 78,000 workers followed for an average of 21 years, with more than 1.6 million person years of observation, establish that there is a statistically significant 15% excess risk of brain cancer for workers in the U.S. nuclear industry who have low-dose average cumulative radiation exposures.

Brain Neoplasms↗