Biomedical subjects

V Asaf

Publications and source records attributed to V Asaf.

4 recordsLinked to original sources

PubMed2001

[Primary peritonitis due to Streptococcus pyogenes].

Most infections causing by Streptococcus pyogenes are known to be putrid both in adults and children, for example laryngitis, impetigo, cellulitis, scarlet fever, septic shock, toxic shock syndrome etc. Their clinical importance relates to a number of causes: 1) about 20% of the population are S. pyogenes carriers; 2) the clinical course of infections is often severe or even fatal; 3) there is real danger of nosocomial outbursts; 4) a world-wide increase in both the rate and invasiveness of the microbe. Acute primary peritonitis due to S. pyogenes seems to be a rare clinical event. In order to stimulate physicians' attention to the issue, we decided to describe the case of a child with the primary peritonitis due to S. pyogenes. Early diagnosis and surgical intervention combined with the proper antibiotic treatment appeared to be life-saving.

Cefuroxime↗

PubMed1995

Abolition of postprandial alkaline tide in arterialized venous blood of duodenal ulcer patients with cimetidine and after vagotomy.

OBJECTIVE: Alkaline tide is the observed alkalinization of blood and urine after stimulation of gastric acid secretion. In previous studies, we found good correlation between gastric acid output and alkaline tide in arterialized venous blood. METHODS: In the present study, the alkaline tide phenomenon was further investigated in 26 duodenal ulcer patients (seven post-vagotomy) after a test meal, before and after cimetidine pretreatment. RESULTS: Alkaline tide was demonstrated in everyone of the 19 duodenal ulcer nonvagotomized patients but in only two of the seven vagotomized patients; base excess mean rise of 1.05 +/- 0.14 mEq/L/45 min versus -.07 +/- 0.23 mEq/L/45 min (mean +/- SE, p < 0.001). Decrease in alkaline tide after cimetidine was demonstrated in the nonvagotomized group: 1.05 +/- 0.14 mEq/45 min versus -0.03 +/- 0.16 mEq/45 min, before and after cimetidine, respectively (mean +/- SE, p < 0.001). Urinary alkaline tide was demonstrated in only 4/19 and 2/19 of the first group (with and without cimetidine, respectively) and in only 1/7 of the post-vagotomy group. CONCLUSIONS: Our results suggest an association between gastric acid secretion and blood alkaline tide, because both are inhibited by cimetidine or vagotomy.

Adult↗

PubMed1992

Open-access, flexible, fiberoptic sigmoidoscopy in a regional primary-care clinic.

We established an open-access, flexible, fiberoptic sigmoidoscopy service in an outpatient clinic in Kiriat-Shmona, Northern Israel. Twenty-eight general physicians in the city and in 41 surrounding rural residences (population 40,000) were encouraged to refer patients for sigmoidoscopy. In the first operative year, flexible sigmoidoscopy was performed on 255 patients (age range 10-90 years, mean 54). The male to female ratio was 123:132; women were slightly older than men (mean age 55.9 years vs. 51.1). Rectal bleeding and change in bowel habits were the most common indications. The sidmoidoscope was passed to the splenic flexure in 156 patients (61%). In five patients (2%) the instrument could not be inserted beyond the rectosigmoid junction. Excluding hemorrhoids and anal lesions, abnormalities were detected in 69 patients (27%). In 29 patients (11.4%) a cancer or polyp was found. Analysis of referral indications showed an increased positive predictive value for neoplastic lesions in patients referred for anemia (22.2%), weight loss (20.0%), abdominal pain (17.8%), and positive fecal occult blood test (15.4%). There were only two patients with polyp or cancer of 55 (3.6%) < 40 years of age, in contrast to 27 of 200 (13.5%) > 40 (p < 0.05). Sixty-six patients underwent further investigation, and 26 had positive results: colonic lesions were confirmed in 20 patients, sigmoid colon cancer was found on barium enema in one, and lesions outside the colon were detected in seven. Such open-access, flexible sigmoidoscopy gave higher yield for colorectal polyps or cancers than open-access or hospital-initiation barium enema.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1991

[Closure of postoperative anastomotic fistulas with a somatostatin analogue].

Postoperative gastrointestinal fistula formation is not rare, and is accompanied by considerable morbidity and mortality. Somatostatin, a potential, universal endocrine and exocrine inhibitor, is a peptide synthesized in the nervous system and the gastrointestinal tract. We describe 2 men, 58 and 53 years old, respectively, with postoperative fistulas, the first after pancreatic-jejunal and the second after jejunal anastomosis. 7 and 3 days, respectively, after starting a synthetic somatostatin analogue (SMS 201-995), discharge from the fistulas decreased and they closed completely.

Anastomosis, Surgical↗