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V B Koziner

Publications and source records attributed to V B Koziner.

At least 19 recordsLinked to original sources
PubMed1991

[Comparative characteristics of the effectiveness of oxygen delivery to the tissues by human erythrocytes preserved with glugicir and citroglucophosphate].

The main parameters of hemodynamics and oxygen regimen were investigated in isolated rat heart (130 tests) during its perfusion with red blood cells preserved in glugicir (GGC) and citroglucophosphate (CGP). Short-term storage red blood cells did not show disorders in O2 transport to tissues. Long-term storage red blood cells (both in GGC and CGP) showed disorders in hemodynamics that were associated with appearance of free hemoglobin in the perfusion medium due to disruption of some red blood cells by the perfusion apparatus.

Animals↗
PubMed1989

[The oxygen supply of the isolated rat heart during perfusion with a suspension of human erythrocytes prepared on the blood preservative citroglucophosphate].

The isolated rat heart with the functioning left ventricle was used to measure the main parameters of hemodynamics and oxygen supply (60 experiments). Perfusion of the coronary vessels of the heart was performed with washed human red blood cells preserved for varying times (for 1, 7, 10, 14 and 21 days), stabilized on citroglucophosphate. The authors succeeded for the first time in demonstrating under artificially made conditions where the sole variable responsible for oxygen supply of the isolated organ was hemoglobin affinity for oxygen that there was no difference in the function of the isolated heart perfused with human red blood cells preserved for 7, 10 and 14 days as compared with freshly obtained ones. During perfusion of the heart with red blood cells preserved for an insignificant period of time (for 7 and 10 days), no physiological signs evidencing the impairment of oxygen supply to myocardial tissues were revealed.

Animals↗
PubMed1984

[Treatment of experimental metabolic alkalosis by sorbamine].

A new infusion solution called alkamine has been developed for the treatment of metabolic alkalosis. It contains amino acids in the form of hydrochlorides (arginine, lysine and histidine hydrochlorides), potassium chloride and sorbit. The solution has been tested in anesthetized cats with experimental metabolic alkalosis induced by the injection of sodium hydrocarbonate solution. In control experiments without any therapy, a stable alkalytic shift of acid-base balance in the blood, a fall in the blood pressure, hypopotassemia and death of the animals within the first days were observed after experiments. The treatment of metabolic alkalosis by alkamine (25 experiments) entailed a complete correction of acid-base balance and hypopotassemia, stabilization of blood pressure and the survival of 23 out of the 25 animals. Alkamine solution has been approved for clinical trials by the Pharmacological Committee of the Ministry of Health of the USSR.

Acid-Base Equilibrium↗
PubMed1981

[Possibility of supporting life by breathing oxygen after complete blood replacement with a blood substitute].

It has been shown in experiments on cats that during complete blood replacement by polyglucin and in oxygen respiration, the life of the animals can be supported for 8-9 hours. The control animals which inspired the atmospheric air rapidly died. The animals' survival was promoted by high partial oxygen pressure in the air inspired, by a greater blood flow and constant volume of the circulating blood.

Air↗