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Biomedical subjects

V Babu

Publications and source records attributed to V Babu.

6 recordsLinked to original sources
PubMed2001

Anesthetic management of patients with Takayasu's arteritis: a case series and review.

UNLABELLED: Takayasu's arteritis is a rare, chronic progressive panendarteritis involving the aorta and its main branches. Anesthesia for patients with Takayasu's arteritis is complicated by their severe uncontrolled hypertension, end-organ dysfunction resulting from hypertension, stenosis of major blood vessels affecting regional circulation, and difficulties encountered in monitoring arterial blood pressure. Takayasu's arteritis is an uncommon disease and previous descriptions of the anesthetic management of patients with this disease have been limited to isolated case reports in the anesthetic literature, mostly in women undergoing cesarean delivery. We present our experience in this series of eight patients for various emergency and elective surgical procedures and review their perioperative problems and management. IMPLICATIONS: This case series describes the anesthetic problems and management of patients with pulseless disease.

Adult↗
PubMed1998

A rare case of hereditary multiple impacted normal and supernumerary teeth.

An eight-year-old girl residing in Bangalore presented with a complaint of retained primary maxillary and mandibular incisors. Radiographic examination of the case revealed multiple impacted permanent succedaneous teeth with deficient resorption of primary teeth and multiple impacted supernumerary teeth. Family history revealed that the mother also exhibited multiple impacted supernumerary teeth. Based on the clinical presentation, radiographic examination and histopathological studies, this paper discusses the differential diagnosis and management of such a case.

Child↗
PubMed1995

Ultraviolet-B effects on ocular tissues.

The enhancement of UVB on the surface of the earth due to stratospheric ozone depletion may increase the risk of photochemically induced cataract. In this study, changes in the content of certain biological parameters were used as a marker to study ocular toxicity. A significant enhancement in the level of H2O2, LP and Pi, along with the depletion of GSH (antioxidant-defence system) in serum, aqueous humor and lens of albino mice exposed to UVB was observed. The level of Ca++ increased in serum and aqueous humor but decreased considerably in the lens due to increase in UVB exposure. These observations provide further clues to support the involvement of oxidative stress and Ca++ in the events leading to the formation of cataract.

Animals↗
PubMed1994

Single-stage reconstruction of soft-tissue defects including the Achilles tendon using the dorsalis pedis arterialized flap along with the extensor digitorum brevis as bridge graft.

Open ruptures of the Achilles tendon with loss of the tendon and the overlying skin are very difficult to treat. They pose the problems of (1) combating infection, (2) providing soft-tissue cover, and (3) bridging the gap in the tendon. They are generally managed as multi-staged procedures. Once the infection is brought under control with debridement and antibiotics, skin cover is provided by local transposition flaps, distant pedicle flaps, or free-tissue transfer with microvascular anastomoses. The tendon itself is repaired later by one of the conventional techniques. More recently, composite free-tissue transfers repairing the skin and tendon in a single stage have been reported. We describe a simple and very reliable procedure using a dorsalis pedis island flap which provides a vascularized, innervated musculotendinous unit (i.e., extensor digitorum brevis) to bridge the gap in the Achilles tendon and thin, mobile skin and fascia to close the defect in the skin. Two cases are presented, including the technical details, advantages, and limitations of this procedure.

Achilles Tendon↗
PubMed1992

Tryptophan as an endogenous photosensitizer to elicit harmful effects of ultraviolet B.

Owing to stratospheric ozone depletion (SOD) the natural flux of ultraviolet B (UVB) radiation (290-320 nm) is likely to increase on the earth surface. In our efforts to identify endogenous chromophores which may absorb significantly in the UVB range and subsequently induce phototoxic reactions, we have observed that tryptophan (Trp) was quite photoreactive under UVB. It enhanced considerably the oxygen-dependent photooxidation of tyrosine (Tyr) to dopachrome, a precursor of melanin. Our data suggest that UVB-sensitized Trp produces singlet oxygen (1O2) and superoxide radicals (O2-.), and these reactive forms of oxygen may contribute to membrane-, cytoplasm- and DNA-damaging effects. In the event of an increasing SOD level, other UVB chromophores may also exhibit similar phototoxic properties to lead to a definitive imbalance between cell life, injury and death.

Dihydroxyphenylalanine↗