Biomedical subjects

V Ball

Publications and source records attributed to V Ball.

22 records · Page 2Linked to original sources

PubMed1987

A microprocessor-based acoustic hearing aid for the profoundly impaired listener.

We have found that the larynx-frequency pattern of speech presented as a sinusoid can be of greater communicative value to profoundly hearing-impaired people than the complete acoustic signal. The presence of higher harmonics can give poorer labelling of isolated intonation contrasts and often minimal gain in segmental spectrally-based distinctions. These observations have led to the development of a practical, body-worn, pattern-processing hearing aid that uses a microprocessor to sense the (analogue-processed) speech fundamental frequency, transform it into an appropriate amplitude and frequency region, and generate digitally the required output sinusoid. Our findings have important implications for the design of other signal-processing hearing aids in demonstrating that a simplification of speech can lead to enhanced speech receptive abilities in persons with impaired hearing.

Adult↗

PubMed1986

Speech perception with the Vienna extra-cochlear single-channel implant: a comparison of two approaches to speech coding.

Although it is generally accepted that single-channel electrical stimulation can significantly improve a deafened patient's speech perceptual ability, there is still much controversy surrounding the choice of speech processing schemes. We have compared, in the same patients, two different approaches: (1) The speech pattern extraction technique of the EPI group, London (Fourcin et al., British Journal of Audiology, 1979,13,85-107) in which voice fundamental frequency is extracted and presented in an appropriate way, and (2) The analogue 'whole speech' approach of Hochmair and Hochmair-Desoyer (Annals of the New York Academy of Sciences, 1983, 405, 268-279) of Vienna, in which the microphone-sensed acoustic signal is frequency-equalized and amplitude-compressed before being presented to the electrode. With the 'whole-speech' coding scheme (which they used daily), all three patients showed an improvement in lipreading when they used the device. No patient was able to understand speech without lipreading. Reasonable ability to distinguish voicing contrasts and voice pitch contours was displayed. One patient was able to detect and make appropriate use of the presence of voiceless frication in certain situations. Little sensitivity to spectral features in natural speech was noted, although two patients could detect changes in the frequency of the first formant of synthesised vowels. Presentation of the fundamental frequency only generally led to improved perception of features associated with it (voicing and intonation). Only one patient consistently showed any advantage (and that not in all tests) of coding more than the fundamental alone.

Adult↗

PubMed1985

Audiological rehabilitation of patients with brainstem disorders.

A brief account is given of the course of rehabilitation of three patients with severe brainstem injuries. Particular use has been made of synthetic speech pattern assessment procedures which have been integrated into the management model of Goldstein and Stephens (1981). The use of speech stimuli of controllable simplicity has two main clinical benefits: the early course of re-acquisition can be examined analytically, second, aspects of speech receptive and productive rehabilitation can be facilitated. Re-acquisition of perceptive ability in some of these patients may follow a progression from simple to complex acoustic pattern contrasts and this may provide an effective basis for future techniques of rehabilitation.

Adult↗

PubMedDate not supplied

Secondary structure of proteins adsorbed onto or embedded in polyelectrolyte multilayers.

The structural changes of bovine serum albumin (BSA) and hen egg white lysozyme (HEL) upon their adsorption onto the surface or their embedding into the interior of poly(allylamine hydrochloride)-(poly(styrenesulfonate) (PAH-PSS) multilayer architectures were investigated by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. The presence of the polyelectrolytes seems, as previously observed for fibrinogen (J. Phys. Chem. B 2001, 105, 11906-11916), to prevent intermolecular interactions and, thus, protein aggregation at ambient temperature. The secondary structure of the proteins was somewhat altered upon adsorption onto the polyelectrolyte multilayers. The structural changes were larger when the charges of the multilayer outer layer and the protein were opposing. The adsorption of further polyelectrolyte layers onto protein-terminated architectures (i.e., embedding the proteins into a polyelectrolyte multilayer) did not cause considerable further changes in their secondary structures. The capacity of the polyelectrolyte architectures to delay the formation of intermolecular beta-sheets upon increasing temperatures was not uniform for the studied proteins. PSS in contact with HEL could largely prevent the heat-induced aggregation of HEL. In contrast, PAH had hardly any effect on the aggregation of BSA. The differences are explained on the basis of protein-polyelectrolyte interactions, affected mostly by the nature and the strength of the ionic interactions between the polyelectrolyte-protein contact surfaces.

Adsorption↗