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Biomedical subjects

V Belan

Publications and source records attributed to V Belan.

23 records · Page 2Linked to original sources
PubMed1991

[Is it necessary to begin therapy with orchiectomy in patients with advanced stage testicular tumors?].

Seven patients with germ cell tumours of the testis in advanced stages of the disease were treated by primary chemotherapy without previous orchidectomy. To achieve complete remission it was necessary to remove the residual tumour in five patients (in two from the lungs and in three from the retroperitoneal space). Two of the seven patients had a persisting vital tumour in the ectomized testis. Five patients survive in complete remission for an average period of 9.6 months (range 3-18 months) after termination of treatment. In patients with germ cell tumours of the testis in advanced stages of the disease primary chemotherapy should be preferred and treatment should not be started by orchidectomy. Contemporary methods of visualization and laboratory examinations provide adequate evidence of the presence of germ cell tumours and the asset of a rapid effect of chemotherapy on metastases is greater than the advantages of accurate histopathological classification of the tumour. After termination of chemotherapy orchidectomy is indicated because even in patients with complete remission of secondaries a vital malignant tumour may persist.

Adult↗
PubMed1991

[Liver abscess after elective cholecystectomy].

The authors submit the case-history of a 39-year-old patient with elective cholecystectomy where the immediate postoperative course was complicated by a liver abscess. The authors discuss aetiological factors, diagnosis and treatment of liver abscesses. In the conclusion they submit a proposal of ATB prophylaxis in severe inflammations of the gallbladder and biliary pathways. In the department of the authors ATB prophylaxis is not used before elective cholecystectomy.

Adult↗
PubMed1982

Electrophysiological and cyclic AMP responses to beta-adrenergic receptor stimulation and catecholamine levels in cat and rabbit sympathetic ganglion.

The effects of beta 1- and beta 2-selective and nonselective adrenergic agonists and antagonists were studied in the cat and rabbit superior cervical ganglion (SCG) in situ and in vitro. In experiments on the cat SCG in situ beta-adrenergic agonists induced an increase in positive afterpotential (PAP) of compound ganglionic action potential evoked by preganglionic stimulation in the following order of potency: isoprenaline (ISO) greater than salbutamol much greater than tazolol. Beta-adrenergic antagonists inhibited the ISO response in the following order of potency: propranolol greater than exaprolol much greater than H 35/25. Practolol did not exhibit beta-adrenergic blocking action; on the contrary, in higher doses it enhanced the response to ISO. In higher doses all beta-adrenergic antagonists tested depressed ganglionic transmission in an approximately similar range of doses. In experiments in vitro, using sucrose-gap technique. ISO induced depolarization of the cat SCG and this effect was inhibited in a dose-dependent manner by propranolol. Beta-adrenergic agonists did not induce depolarization of the rabbit SCG in experiments in situ and in vitro. The level of noradrenaline and dopamine in the cat and rabbit SCG did not differ significantly. Low level of adrenaline was found in the cat SCG; however, no adrenaline was detected in the rabbit SCG. No statistically significant change of cyclic AMP content was observed in the cat and rabbit SCG or in the incubation medium under conditions similar to those in which ISO induced depolarization of the cat SCG. It is concluded that the beta-adrenergic receptors present in the cat SCG resemble the beta 2-subtype and that the presence of an electrophysiologic response to beta-adrenergic agonists appears to be species-dependent. The depolarization of the cat SCG due to beta-adrenergic receptor stimulation is not coupled with cyclic AMP increase.

Action Potentials↗