[Exacerbation of chronic respiratory failure. Findings in 167 episodes in an intensive care unit].
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Biomedical subjects
Publications and source records attributed to V Bellero.
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Alpha-1 antitrypsin levels were determined in 27 pleural effusion liquids classified as transudates and exudates in accordance with the clinical and laboratory data, and in their respective blood samples. Absolute values proved insufficient to distinguish transudates from exudates, though they were capable of signifying and replacing the relative protein value. The relation between liquid: serum alpha-1 AT ratio and the liquid: serum proteins ratio was direct and highly significant. Along with the liquid: serum LAD and liquid: serum proteins ratios, the liquid: serum alpha-1 AT ratio enables transudates and exudates to be differentiated with certainty.
Lactic acid dehydrogenase (LAD) levels were determined in 82 pleural effusion liquids and the respective blood samples from 58 patients. Effusions were classed as transudates and exudates on the basis of clinical and laboratory data. The 16 transudates had absolute protein levels of less than 3 g/100 ml and a liquid: serum protein ratio below 0.5. LAD values were below 100 mU/ml and the liquid: serum ratio was less than 0.33, whereas both these levels were exceeded in the case of the 66 exudates. The liquid: serum LAD ratio is better suited for the differentiation of transudates and exudates, particularly if it is related to the liquid: serum protein ratio. Neoplastic effusions have the highest absolute LAD values and liquid: serum LAD ratios. Slighter lower values are noted in TB. Taken in conjunction with other parameters, liquid and serum LAD levels enable a transudate to be distinguished from an exudate and assist in aetiological diagnosis.
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