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Biomedical subjects

V Bonnet

Publications and source records attributed to V Bonnet.

32 records · Page 2Linked to original sources
PubMed1995

Increased frequency of bronchial hyperresponsiveness in patients with inflammatory bowel disease.

Although bronchopulmonary manifestations are rare in inflammatory bowel disease (IBD), subclinical abnormalities have been described in up to 50% of cases. The pathophysiology of these abnormalities remains unknown. However, a latent inflammation of the bronchial mucosa secondary to the inflammation of the intestinal mucosa has been suggested. This subclinical inflammation may lead to increased bronchial responsiveness. We studied the bronchial responsiveness in 38 inflammatory bowel disease (IBD) patients, using the methacholine test. Bronchial hyperresponsiveness was defined by a PC20M < 16 mg/ml. Twenty-four healthy controls were also studied. There was no significant difference in baseline FEV1 between IBD patients and controls. However, there was a significantly greater fall in FEV1 in the IBD patients at the concentrations of methacholine tested. The frequency of bronchial hyperresponsiveness was significantly higher in the IBD population (45%) than in controls (17%; P < 0.03). Atopy, defined by skin test, was more common in IBD patients (42%) than in controls (21%). Even when only nonatopic subjects were considered, the frequency of bronchial hyperresponsiveness was significantly higher in IBD patients (41%) than in controls (5%; P < 0.02). Thus, subclinical bronchial hyperresponsiveness is common in IBD, and may be considered a further extraintestinal manifestation.

Adolescent↗
PubMed1994

Potentiation of the twitch responses by inhibitors of sarcoplasmic reticulum Ca(2+)-ATPase in frog atrial fibres.

In frog atrial fibres, cyclopiazonic acid as well as thapsigargin, which are inhibitors of sarcoplasmic reticulum Ca(2+)-ATPase, induced a significant increase in the twitch amplitude without detectable changes in its kinetics. The measurements performed on chemically skinned fibres show that cyclopiazonic acid has no effect on the properties of contractile proteins. In the presence of a T-type Ca2+ channel blocker or L-type Ca2+ channel blocker, cyclopiazonic acid still induced a potentiation of the twitch while no effect was found in the presence of a Na(+)-Ca2+ exchange blocker. The effect of cyclopiazonic acid was not related to any modification in myofibrillar Ca2+ sensitivity or in Ca2+ influx through Ca2+ channels. It is proposed that the inhibition of the sarcoplasmic reticulum Ca(2+)-ATPase resulted in a potentiation of the effect of the Ca2+ influx and that the major role of the sarcoplasmic reticulum was to limit the intracellular Ca2+ concentration.

Animals↗
PubMed1992

[Lipid balance in an arteritic patient and therapeutic implications].

The pathogenesis of atherosclerosis remains hypothetical, the current vogue of a lipidic origin being now only a working hypothesis. The management of an arteritic patient (for a treating clinician) is that of a case of global atherosclerosis. Screening for lipids: 1) is here of only moderate interest in the close scrutiny of currently recognized risk factors, and 2) should include initially a simple study of total plasma cholesterol (TC) and triglycerides (TG) on two occasions at one month's interval in a reliable laboratory. Therapeutic implications are a function of a global analysis of the patient and not just the values for even sophisticated assays of circulating lipids.

Arteritis↗
PubMedDate not supplied

[Evaluating radiotherapy patients' need for information: a study using a patient information booklet] .

The French Radiotherapy-Oncology Society (SFRO) and the National Trade of Radiotherapists-Oncologists (SNRO) elaborated and published a patient information booklet on radiotherapy, in 1999. This present study appraises the pertinence of the form and substance of this booklet one year after its release. Eight radiotherapy centers participated in this research which evaluated 162 patients at treatment initiation. The conclusions of this study demonstrated the importance of clearly informing patients of their disease, treatment, and the secondary effects of treatment. It is essential to emphasize that 97% of the patients declared that an information booklet is a real necessity, and that the one provided by the SFRO responds to the majority of their concerns. Obtaining technical and practical knowledge resulted in a reassurance about their treatment. The most revealing result is that 87% requested direct communication about their illness, and that cancer be named by this word and not other, evasive terms. Seventy-two percent of the patients requested more information about their cancer, different treatment options, and quality of life issues in an attempt to psychologically prepare themselves to face an illness for which they have little control. Patients refuse to be passive, and claim the right to become 'partners' of the medical teams, concerning their treatment and recovery.

Data Collection↗