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Biomedical subjects

V Brezinová

Publications and source records attributed to V Brezinová.

At least 19 recordsLinked to original sources
PubMed1977

Viloxazine, sleep, and subjective feelings.

The sleep of eight volunteers (mean age 55) was recorded electrophysiologically while viloxazine 200 mg was taken daily for 3 weeks, preceded and followed by a week of matching blanks. The volunteers also made ratings of their feelings on visual analogue scales. Another 15 volunteers (mean age 34) took viloxazine 300 mg daily for 3 weeks, preceded and followed by 3 weeks of matching blanks, and they also made daily ratings of feelings. The drug diminished sleep duration and caused more frequent and longer transitions into wakefulness and drowsiness. Slow-wave sleep decreased and stage 2 increased. REM sleep was markedly reduced, especially initially, and there was a withdrawal rebound. Viloxazine impaired subjective concentration mood, and quality of sleep. Three volunteers, however, had striking mood elevation. The drug caused a small loss of weight, which correlated with gastrointestinal symptoms. Three older subjects experienced withdrawal vomiting and prostration. Viloxazine shares properties with imipramine and with amphetamines.

Adult↗
PubMed1977

Smooth pursuit eye movements of schizophrenics and normal people under stress.

Eye movements while watching an oscillating pendulum were recorded in 24 chronic schizophrenies and 24 matched normal controls. As others have reported previously, abnormal tracking movements were significantly commoner in the schizophrenics. However, in a series of experiments with normal subjects it was found that conditions designed to distract attention, or to produce declining arousal and attention, produced abnormal tracking movements indistinguishable from those observed in schizophrenics. As chronic schizophrenics are known to perform badly on a variety of psychomotor tasks and there is evidence that this is due to impaired attention or heightened distractibility, it seems likely that these same factors are responsible for their poor eye-tracking performance.

Adult↗
PubMed1976

Nitrazepam: lastingly effective but trouble on withdrawal.

The sleep of 10 volunteers with an average age of 57 years was recorded electrophysiologically before, during, and after nitrazepam 5 mg nightly for 10 weeks. Sleep was longer and less broken on the drug and no tolerance was obvious after two months' use. Withdrawal of the drug, however, caused sleep to be temporarily worse than before the drug had been taken. Slow-wave sleep was reduced by nitrazepam, but the accompanying secretion of growth hormone was not impaired.

Adult↗
PubMed1976

Do placebos alter sleep?

Deliberate suggestion that an inert capsule was a sleeping pill was found not to influence subjective ratings of sleep quality or anxiety or the electrophysiologically recorded features of sleep in 10 volunteers aged 41-62 years.

Adult↗
PubMed1975

The number and duration of the episodes of the various EEG stages of sleep in young and older people.

Episodes of any one electrophysiological sleep stage and of intervening wakefulness were examined as to their numbers and durations in sleep of ten young normal subjects (mean age 22) and in significantly more disturbed sleep of fourteen late middle age normal people (mean age 55). No significant difference between the two age groups was found for any of the stages in the mean number of episodes taken from 4 nights. For any of the stages, the individual numbers of episodes accumulated over the 4 nights varied in a wide range and showed significant consistency with similar data obtained in another set of 4 nights. There were significant differences between the two age groups in episode duration. The sleep of the older group contained significantly higher proportions of longer episodes of wakefulness and drowsiness and significantly lower proportions of longer episodes of slow wave sleep and REM sleep. Thus, the initiation of episodes of EEG stages was on average similar in the better sleep of young and impaired sleep of older subjects, but the maintaining or termination of the episodes were different.

Adult↗
PubMed1975

Apha-adrenergic receptor blockade increases human REM sleep.

1 An alpha-adrenergic receptor blocking agent, thymoxamine (150 mg i.v.) in the early night sleep of young adults increased REM sleep duration and also brief awakenings in the early night, while slow wave sleep, stage 3+4, was diminished. In the later night, however, stage 3+4 sleep was increased. Control experiments demonstrated that thymoxamine (i.v.) was without effect on blood pressure. 2 REM sleep duration may be inversely proportional to noradrenaline available at central alpha-adrenoceptors, but the control mechanisms for REM sleep appear interdependent with those for NREM sleep.

Adult↗
PubMed1975

Two types of insomnia: too much waking or not enough sleep.

The stability of sleep was examined in two kinds of induced insomnia, namely after caffeine administration and after hypnotic drug withdrawal. The duration of each episode of any one sleep stage or any episode of intervening wakefulness plus drowsiness was determined. After caffeine there was an increase in longer episodes of intervening wakefulness plus drowsiness, but no significant change in the episode duration of any of the sleep stages. In the case of drug withdrawal there was no change in the episode duration of intervening wakefulness plus drowsiness, but there was a significant shortening of episode duration in sleep stages 2 and 3+4, with a similar trend for REM sleep episodes. Caffeine 'insomnia' thus seems characterized by increased stability of wakefulness, and hypnotic withdrawal 'insomnia' by decreased stability fo sleep. The type of analysis undertaken in this study could increase understanding of other types of insomnia.

Age Factors↗
PubMed1975

Plasma growth hormone and slow wave sleep increase after interruption of sleep.

A comparison was made of plasma hGH and of sleep stages during one night of undistrubed sleep and one night in which sleep was interupted by an hour of enforced wakefulness folowing the end of the second NREM-REM sleep cycle in 8 normal subjects. Plasma was sampled at 15-min intervals. HGH and slow wave sleep were both significantly increased in the two cycles immediately following the period awake compared with the same two cycles during nights of uninterruped sleep. The difference arose predominantly in the fourth cycle of the night, i.e., in the second cycle after the sleep interuption. The findings are consistent with the belief that extra wakefulness brings additional sleep of high RESTORATIVE properties.

Adult↗
PubMed1973

Two anti-anxiety drugs: a psychoneuroendocrine study.

Eight males were studied during 27 weeks, including two periods of five weeks during which they received clinical doses of sodium amylobarbitone and benzoctamine. Substitution of placebo for either drug caused raised anxiety and impairment of mental concentration. The drugs reduced restlessness during sleep and reduced paradoxical sleep. By the fifth week of sodium amylobarbitone, although sleep was still less restless in the early night it was more restless than normal in the late night.Blood samples were taken half-hourly during sleep by indwelling venous catheter. Plasma growth hormone concentration was little affected during drug administration but rose temporarily after withdrawal. There was a reduction of plasma corticosteroid concentration during sleep throughout administration of the drugs and a rebound above normal during the first withdrawal week.

Adrenal Cortex Hormones↗
PubMed1972

Sleep after a bedtime beverage.

Sleep after an inert capsule was compared with sleep after a hot, bedtime, milk-cereal drink (Horlicks). All-night electrophysiological recordings were made with 18 persons on 10 nights each.Restlessness during sleep at the end of the night was diminished after Horlicks in a group of 10 young adults. In an older group of eight adults, mean age 55 years, sleep after Horlicks was of longer total duration and was less broken by periods of wakefulness. In the latter group the improvement associated with Horlicks was most apparent late in the night and it increased with repeated administration.

Adult↗