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Biomedical subjects

V Brodan

Publications and source records attributed to V Brodan.

At least 19 recordsLinked to original sources
PubMed1979

Analysis of rapid oscillations of glucose and free fatty acids in plasma.

The authors analyzed rapid oscillations of blood sugar (GL) and free fatty acid levels (FFA) in serum of healthy subjects. They investigated a series of blood samples taken under conditions of absolute rest from the cubital vein at 15-s intervals for a period of 6 min. In addition to common statistical parameters, they calculated the course of autocorrelation and cross-correlation functions and periodograms. The magnitude of oscillations is significantly higher than the error of the biochemical methods. In some sequences periodicities were detected which were statistically significant in 23.8% of GL and in 38.1% of FFA. 24-point series of GL collected in parallel from both arms correlate in 36.3% positively, in 27.3% negatively, and in 36.4% they do not correlate. Series of FFA and GL collected simultaneously from one site correlate mutaually in almost all instances either positively or negatively, frequently with a time shift. The oscillations may be due to (a) feedback regulations of the levels of the two metabolites, (b) permanent mutual interaction between the FFA and glucose level and (c) an uneven concentration of the two metabolites in different parts of the circulation. The above factors may combine, and the list of possible factors may not be complete.

Adult↗
PubMed1979

Simultaneous correction of Ca deficiency and acidosis in fasting obese patients as a prevention of bone demineralisation.

Short-term starvation in the obese induces metabolic acidosis and increased calciuria resulting in severe negative Ca balance. Oral administration of 5 g Ca-lactate daily is capable of correcting acidosis, reducing calciuria and providing the body with 650 mg Ca daily, thereby maintaining a positive Ca balance throughout the period of starvation. We therefore propose administering this amount of the preparation to obese individuals during starvation as a simple and cheap preventive measure against bone demineralisation.

Acidosis↗
PubMed1979

Use of the periodogram in the analysis of high frequency basal blood sugar oscillations in healthy subjects.

Twenty-four triplicate samples of the morning blood sugar of 17 fasting healthy women were taken from the cubital vein with a cannula at 15-sec intervals. The mean value was 4.44+/-0.69 mmol/l and the mean variation range 22.4+/-9.2%. Variability within the sets of three samples was 1.7+/-0.9%. In 23.5% of the cases, statistically significant periodicities (p less than 0.05) were detected by computing the periodogram. In 29.4%, several periodic components (2--4) were detected simultaneously. After deducting harmonic components, the residual scatter fell by an average 43.9%. In four cases the drop was significant in the F test at 1% and in one case at 5% level. The periodic components of the observed oscillations could be due to oscillation in feedback control circuits and the main role in the random component was evidently played by inadequate glucose blending in the circulation.

Adult↗