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V Bustamante Murga

Publications and source records attributed to V Bustamante Murga.

At least 19 recordsLinked to original sources
PubMed2002

[Bone metabolism and bone mass loss in eating disorders].

Eating disorders (anorexia and bulimia nervosa) are present in 1-3% of young female women. A later beginning, prolonged amenorrhea and low body mass index are risk factors of osteopenia in bulimic patients. Bone demineralization in anorexia nervosa is due to a greater resorption than bone formation leading to osteopenia, secondary osteoporosis and increased risk of pathologic fractures. Pathophysiology of bone disease includes factors as long duration of amenorrhea, deficient absorption of calcium, extreme physical exercise, 1.25 vitamin D deficiency, low creatinine clearance, increased blood and urinary cortisol and high levels of GH. Proposed treatments are nutritional improvement and weight gain (the most important), calcium supplementation, moderate exercise, estrogens, antidepressive drugs, fluoride in selected cases, byphosphonates and recombinant human IGF-1. An adequate questionnaire is essential in women with slightly decreased weight and menstrual disorders.

Anorexia↗
PubMed1998

[Primary adrenal failure and AIDS: report of 11 cases and review of the literature].

OBJECTIVE: To know the prevalence of adrenal insufficiency (AI) in our patients with acquired immunodeficiency syndrome (AIDS) and to compare the clinical manifestations with those reported in previous series in the literature. PATIENTS AND METHODS: Retrospective study with review of clinical records of patients with AIDS diagnosed of AI (plasma cortisol after synthetic ACTH < 18 micrograms/dl) in our hospital for a period of 6 and a half years. RESULTS: Eleven out of 65 patients (17%) with the hormonal study performed were diagnosed of AI. The prevalence of AI in our patients with AIDS was 1.66%. The response of plasma cortisol to synthetic ACTH was abnormal in the 11 patients (mean increase: 1.89 micrograms/dl). Nine out of the 11 patients had a decreased basal plasma cortisol level (mean: 4.75 micrograms/dl). Basal plasma ACTH levels were increased (mean: 638.9 pg/ml) in seven out of nine patients. Patients were severely immunosuppressed (mean CD4: 21/microliter). While the clinical course was subacute (mean: 5.1 weeks), nine out of the eleven patients developed an adrenal crisis which required emergency therapy. Ten patients had an opportunist infection--M. tuberculosis (3), M. avium-intracellulare (3), Cytomegalovirus (3), histoplasmosis (1)--which could involve the adrenal glands in ten patients. All patients responded to treatment but their mean survival was 5.6 weeks. CONCLUSIONS: Although the prevalence of AI in our patients with AIDS was low (1.66%), it is important to be aware of the disease and to order a basal plasma cortisol value after synthetic ACTH, as treatment improves the life quality of patients if AI is confirmed, despite a short survival time.

AIDS-Related Opportunistic Infections↗
PubMed1991

[Yersiniosis in a general hospital in the Basque country (1984-1989). Clinical and epidemiological aspects].

BACKGROUND: The features of the diseases caused by Yersinia have not been properly evaluated in the Basque Country. The present study was performed to assess the incidence and consequences of this infection. METHODS: 51 cases of Yersinia infection in a general hospital during the period 1984-1989 were reviewed. Clinical, epidemiological, microbiological, and therapeutic data and the hospital stay were evaluated. RESULTS: 62% of patients were males with a mean age of 16 +/- 19.4 years. Most came from urban areas. 40% of cases developed in winter and 32% in summer. The presenting features were: acute gastroenteritis (66%), pseudoappendicitis (10%), sepsis (4%), lymphadenopathy (2%) and others (18%). 40% of the patients had significant underlying diseases, and 16% had complications attributable to the infection. The microbiological diagnosis was made by stool culture in 88%. 96% corresponded to Yersinia enterocolitica (biotype 4), serogroup 0: 3 (93%). Yersinia pseudotuberculosis was isolated from the culture of a cervical lymph node in one patient. In the Yersinia enterocolitica strains the most common antibiotic resistances were to ampicillin (87%), cephalotin (81%), ticarcillin (75%), mezlocillin (43%) and piperacillin (43%). The mean hospital stay was 6.1 +/- 12.2 days and it was significantly shorter in children (3.3 +/- 6.1%) than in the adult population (10.9 +/- 17.4) (p less than 0.05). It was longer in patients with underlying diseases (13.3 +/- 17.8 vs 3.3 +/- 5.6) (p less than 0.005). CONCLUSIONS: Our patient population had male and urban predominance. Most infections were caused by Yersinia enterocolitica and presented as acute gastroenteritis, without differences between winter and summer. We point out to the relationship between Yersinia infection, abnormalities in iron metabolism and immunosuppression. There were few complications of the infection. The mean hospital stay was directly correlated with age and underlying diseases.

Adolescent↗
PubMed1980

[Familial hypertrophic neuropathies. Conceptual and critical outline. Report of a family with Dyck and Lambert's type IV disease (author's transl)].

The authors make a historical and critical summary of the clinical development of hypertrophic neuropathies up to the classification established by Dick and Lambert, based on its clinical, electrophysiological and genetic study. Until more light is shed on the etiology of these diseases by the metabolic studies already initiated, the use of such classification is recommended. Based on this point of view the clinical, electrophysiological and pathological study of five members of a peculiar family is presented. The affected members presented clinically with different stages of evolution of the uncommon form defined as type IV by Dick and Lambert.

Adolescent↗
PubMed1979

[Pulmonary tuberculosis in the outpatients clinics of the Social Security in Biscay (author's transl)].

The authors review the problem of active pulmonary tuberculosis in the clinics of the Social Security in Biscay. The high number of cases offers a wide panorama and the possibility of arriving at general conclusions within the Biscayan demographic structure. It is rather disturbing to discover an average of 24.37 cases per 100,000 inhabitants per year in this partial study of the situacion. The indexes for 1967 and 1974 were practically the same. Although the disease occurs with greatest frequency in persons between 30 and 60 years of age, there is a marked tendency for it to appear at increasingly lower ages. The disease is much more common in men than in women, and immigrates seem to be more susceptible than the native population. Pulmonary tuberculosis was reported as the cause of 1.12 percent of the 61,341 deaths registered in Biscay during the 8-year period under study (1967-1974). In view of this situation the authors insist on the urgent need for strategic methods to erradicate this serious menace to public health. They consider the role of tuberculosis sanatoriums in the state to be of outmost importance.

Adolescent↗