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Biomedical subjects

V C Ohri

Publications and source records attributed to V C Ohri.

18 recordsLinked to original sources
PubMed2001

Plasmid mediated antibiotic resistance in Klebsiella pneumoniae.

Klebsiella pneumoniae species (108) isolated from tertiary care hospitalized patients were investigated for antibiotic resistance patter. 74% isolates were from urine, 13.5% from pus, 4.5% from blood and 8% from sputum. The resistance pattern of the organisms to various antibiotics were as follows: ampicillin 93.3%, cefotaxime 70%, ceftazidime 81%, gentamicin 68.5%, amikacin 63.75%, netilmicin 74%, norfloxacin 55%, ofloxacin 53%, chloramphenicol 82%, tetracycline 85%, sulphamethoxazole 96%, trimethoprim 94%. 2-4 drug resistance was found in 34.5%, 5-8 drug resistance was in 25.1% and 9-12 drug resistance was found in 40.4% of strains. Out of 65 strains, 25 strains could be successfully conjugated. Common drugs which were transferred to transconjugants were sulphamethoxazole, trimethoprim, gentamicin, netilmicin, amikacin, chloramphenicol, tetracycline, ampicillin, cefotaxime and ceftazidime. A large plasmid of 98.7% kb could be demonstrated in these strains by alkali denaturation method and agarose gel electrophoresis.

Anti-Bacterial Agents↗
PubMed1997

Subcutaneous and osteolytic rhinosporidiosis.

A young man presented with multiple Subcutaneous nodules over scalp, hand, feet and osteolytic lesions of small bones of hand. Clinically and radiologically he was diagnosed as a case of Giant Cell Tumour. Aspiration cytology and biopsy proved it to be rhinosporidiosis. Epidemiological study revealed that he perhaps contracted this infection as an occupational hazard. This is the third reported case of osteolytic lesions due to rhinosporidiosis. Diagnostic dilemmas of subcutaneous and osteolytic rhinosporidiosis are discussed.

Adult↗
PubMed1991

Excessive polycythaemia of high altitude. Pulmonary function studies including carbon monoxide diffusion capacity.

Pulmonary function studies were done in 21 soldiers (low landers) posted at high altitude (average height 4773 metres) for prolonged periods (average 77.09 months), who had developed excessive polycythaemia, mean haemoglobin concentration being 23.06 g/dl. Studies revealed significant reduction in diffusion capacity of lungs which gradually returned to normal on sojourn at low altitudes for 70 days. Both the degree of polycythaemia and reduction in lung diffusion capacity were much more pronounced in smokers than in non-smokers. Vital capacity did not show any difference in these subjects while forced expiratory volume in 1 sec and ratio of forced expiratory volume to vital capacity (FEV1/VC) revealed only obstructive features in smokers.

Adaptation, Physiological↗
PubMed1984

Effect of digoxin on serum and urinary cation changes on acute induction to high altitude.

Forty subjects each were rapidly inducted by road to altitudes of 3200 and 3771 meters (m). Half of subjects at each altitude were maintained on digoxin and the other half received placebos. The digoxin group showed higher serum potassium at both altitudes. Serum sodium remained unaltered. When compared to control groups, urinary volume changes were less marked in the digoxin group. Similarly, the alterations in calcium and magnesium in serum and urine at 3771 m were less pronounced. However, none of these changes in the digoxin groups were statistically significant when compared with control groups.

Adult↗
PubMed1982

Platelet count, platelet aggregation and fibrinogen levels following acute induction to high altitude (3200 and 3771 metres).

Two groups of 20 subjects each were separately exposed to altitudes of 3200 m and 3771 m for 10 days by rapid induction requiring 14 and 16 hours respectively to reach high altitude camps. A statistically significant fall in platelet counts was observed from day 2 at 3200 m and day 3 at 3771 m and counts remained decreased. Platelet aggregation was also decreased initially at both altitudes. Blood fibrinogen decreased only on day 2 at 3771 m with a significant increase over control values by day 10 at both altitudes.

Adult↗
PubMed1982

Serum and urinary cation changes on acute induction to high altitude (3200 and 3771 metres).

Twenty subjects each were rapidly inducted by road to 3200 ad 3771 m. Serum and urinary sodium, potassium, calcium, and magnesium were measured during 10 d at high altitude. At 3200 m, only serum potassium increased significantly on the 10th day. At 3771 m, serum potassium did not increase. Serum sodium generally remained low, serum magnesium increased, while calcium decreased significantly. Urinary volume over 24 h decreased more and for longer duration at 3771 m than at 3200 m. Urinary cations did not change significantly at 3200 m. At 3771 m, sodium and potassium excretion decreased on days 1 and 3 later returned towards preinduction levels. Magnesium and calcium decreased throughout the high-altitude stay. Significant changes were noticed in serum and urinary cations on exposure to high altitude when adequate caloric intakes were not ensured.

Adult↗