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Biomedical subjects

V Christensen

Publications and source records attributed to V Christensen.

At least 37 records · Page 2Linked to original sources
PubMed1978

Haemodynamic effects of enflurane in patients with valvular heart disease.

In eight patients undergoing cardiac surgery for aortic and/or mitral valvular disease, mean arterial blood pressure (MAP), central venous pressure (CVP), cardiac index (CI), stroke index (SI), pulmonary capillary wedge pressure (PCWP), and pulmonary arterial mean pressure (PAMP) were measured after premedications with diazepam-scopolamine (I), after breathing 100% oxygen (II), and on controlled respiration (III) after induction of anaesthesia with enflurane-O2, and endotracheal intubation facilitated by succinylcholine. All measurements were done prior to surgery. Enflurane anaesthesia was found not to affect cardiac index. The average SI decreased by 27%, but was compensated for by an average increase in heart rate (HR) of 33%. The average systemic vascular resistance (SVR) decreased by 14%. All other measured parameters were found to be unaffected by enflurane-O2 anaesthesia. It is concluded that the cardiovascular stability observed in healthy young normals during enflurane anaesthesia is preserved in patients with moderate to severe heart failure, making enflurane an anaesthetic agent well suited for patients with cardiac disease.

Anesthesia, Inhalation↗
PubMed1978

Intravenous lidocaine as a suppressant of persistent cough caused by bronchoscopy.

The effect of intravenous lidocaine in the treatment of persistent cough occurring after diagnostic bronchoscopies performed under general anaesthesia was investigated in a controlled clinical trial. The study comprised 28 adults patients, all of whom had regained consciousness after anaesthesia. Fifteen patients were treated with lidocaine (1.05 mg/kg body weight) and 13 patients with placebo (saline). In each patient the intravenously injected dose was repeated once after 5 min. In 11 of the 15 patients (73%) who received lidocaine coughing ceased, while it continued in all 13 patients in the placebo group. The difference is highly significant (P less than 0.001). None of the patients developed side effects such as hypotension, arrhythmias, central nervous system symptoms or respiratory depression after injection of lidocaine. It is therefore concluded that intravenous lidocaine in man is a safe and useful cough-suppressant.

Aged↗
PubMed1977

Halothane anaesthesia ans suxamethonium II. The significance of preoperative gallamine administration.

Preoperative administration of gallamine was evaluated during inhalation anaesthesia with nitrous-oxide and halothane with two administrations of suxamethonium 1 mg/kg body weight, 5 min apart. Sixty healthy patients were randomly divided into three groups and preanaesthetic gallamine, 0.3, 0.4 or 0.5 mg/kg body weight, respectively was administered intravenously 3 min before induction, according to the allocation. Just before induction of anaesthesia the patients were examined for signs and symptoms of partial curarization. After induction of anaesthesia by nitrous-oxide-oxygen-halothane, suxamethonium 1 mg/kg was given intravenously. Exactly 5 min later the same dose was repeated. ECG was monitored continuously and serum potassium, Pao2 and Paco2 were measured at appropriate intervals. It was found that none of the examined doses of gallamine gave any reliable protection against serious bradyarrhythmias after repeated doses of suxamethonium. Furthermore the higher doses of gallamine caused an unacceptably high frequency of patients with tachycardia and signs and symptoms of partial curarization.

Adolescent↗
PubMed1975

Effects of general anaesthetics on the pH of gastric contents in man during surgery: a survey of halothane, fluoroxene and cyclopropane anesthesia.

The effect of premedication and three general anaesthetics on gastric content pH was investigated. Neither premedication with pentobarbital-atropine nor morphine-scopolamine given 1-2 h prior to anaesthesia appeared to affect the acidity of the gastric contents. Halothane invaribly increased the pH of the gastric contents; none of the seven patients studied had a gastric pH of less than 2.5 (mean 5.1) after 1 h of anesthesia. Cyclopropane uniformly maintained the acidity of the gastric contents; only one out of seven patients had a gastric content pH above 2.5 (mean 1.7) after 1 h of anaesthesia. This effect of cyclopropane in maintaining the pH of gastric contents was unaffected by the use of premedication and induction with thiopental. Fluorexene affected the pH of the gastric contents much less uniformly. Although the pH for the group as a whole gradually increased (after one hour from 1.7 plus or minus 0.2 (s.e. mean) to 3.1 plus or minus 0.7), some of the seven patients studied reacted to fluroxene with a constant low gastric content pH. The findings are discussed, and it is concluded that the risk of pulmonary complications in case of vomiting and aspiration upon emergence from anaesthesia is greater if the anaesthetic agent is cyclopropane or fluoroxene, than if it is halothane.

Anesthesia, General↗
PubMed1975

Congenital duodenal adhesions.

Four cases of congenital duodenal adhesions are reported. Primary treatment was the freeing of adhesions, but gastrojejunostomy was also necessary in one patient. The patients have now been followed for from 6 months to 3 1/2 years after operation, and are all well. Diagnois is difficult and can be confused with ulcer. In 2 patients, preoperative differential diagnois included duodenal adhesions, but the other 2 patients underwent laparotomy on the prospective diagnosis of duodenal ulcer.

Adult↗