PubMed Health⌕ Search

Biomedical subjects

V Chudomel

Publications and source records attributed to V Chudomel.

At least 55 records · Page 3Linked to original sources
PubMed1979

Progenitor white cells and serum inhibitors in patients with bone marrow aplasia.

In patients with various blood diseases, especially with bone marrow hypoplasia following parameters were determined: presence of antibodies against autologous bone marrow, number of granulocyte-progenitor cells in short term bone marrow cultures and stimulating or inhibiting factors in patient's serum influencing the proliferative activity of bone marrow colonies. The results as well as possible clinical aspects are discussed.

Anemia, Aplastic↗
PubMed1976

Effect of antibiotics and chemotherapeutics on the cytotoxic reaction between HL-A antigens and corresponding sera.

Effects of antibiotics and chemotherapeutics on the interaction between the HL-A antigens and the corresponding lymphocytotoxic sera vary from case to case. Streptomycin, oleandomycin, cephaloridine and kanamycin completely inhibit the cytotoxic reaction when added in the first or second stage of the test. Cytembena weakens the reaction while chlortetracyclin exhibits various effects. The rest of the drugs under investigation proved ineffective.

Anti-Bacterial Agents↗
PubMed1976

Inactivation of HL-A antigens in vitro by action of antibiotics.

The effect of antibiotics on lymphocyte HL-A antigens in vitro is of variable character. All antibiotics under examination suppressed the absorption capacity of HL-A antigens after 2 hr of lymphocyte treatment at 37 degrees C. Ceporin and Kanamytrex inhibited even the cytotoxic reactivity of Hl-A antigens after 15-30 min of lymphocyte treatment. Chloramphenicol, aureomycin, streptomycin and oleandomycin, on the contrary, increased the specific cytotoxic reactivity of HL-A antigens after 15-30 min, after 1 hr they were ineffective for HL-A antigens, and after two or more hours they produced polyreactivity. Penicillin and erythromycin produced polyreactivity after only 15-30 min. The results show that for the follow-up of the drug effect on HL-A antigens the absorption test rather than the cytotoxicity test is of importance. The suppressed absorption capacity of HL-A antigens caused by the action of antibiotics proves their inactivation effect on the lymphocytes. The possibility of an analogous effect of antibiotics on lymphocyte HL-A antigens, even after administration to patients, is discussed.

Anti-Bacterial Agents↗
PubMed1975

Autoimmunity as possible evoking factor of some so-called idiopathic bone marrow hypoplasias.

Patients with bone marrow hypoplasia or aplasia were examined using the method of lymphocyte blast transformation and the MIF production test. The experimental results demonstrated the presence of an autoimmune process in these patients. A good congruence of the methods was demonstrated. Possible role of the autoimmune process in the pathogenesis of the disease as well as the reasons for the autoimmunity development and the therapeutical implications of these findings are discussed.

Autoantibodies↗
PubMed1975

[Studies on changes in lymphocyte HL-A antigens during the course of malignant diseases].

The presence of HL-A antigens 1, 2, 5, 7, 8 and 12 on the lymphocytes of 26 patients with blood diseases and malignant tumours was examined by means of the two-step microcytotoxicity test. The studies carried out several times in the course of the disease and with 4 to 5 sera of the same specificity. Two types of the serological modifications were found: 1. Transient loss of HL-A antigens in 6 patients, 2. Evidence of the polyreactivity of lymphocytes in 3 patients. The polyreactivity was later changed to the loss of HL-A antigens. In one patient, the destruction of lymphocytes in the course of the testing was proved. The importance of the results is discussed. The additional serological, morphological and clinical investigations seems to be necessary.

Antibody Specificity↗