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Biomedical subjects

V Cvetković

Publications and source records attributed to V Cvetković.

12 recordsLinked to original sources
PubMed1990

[The surgical anatomy of the sublingual gland].

Because of its position, the sublingual gland is clinically important especially in the events of injuries and infections in the anterior part of the sublingual region. The morphology and relationships of this gland were studied by dissection methods applied on 80 fresh or formaldehyde fixed preparations of the mouth floor and of the tongue, which were partly (31 preparations) taken out together with the mandible. As for the shape of the gland, three main types were found: the cuneiform type which was the most frequent (71%), the pyramidal type which was less frequent (16%) and the fusiform type (13%) which comprised the case of a very elongated gland (up to 65 mm). The space in which the gland lied had four walls. Its internal wall consisted of the mylohyoid muscle and it comprised the hyoglossus muscle as well when the gland was very elongated. The inferior wall consisted of the mylohyoid muscle and sometimes it comprised also a narrow part of the superior surface of the geniohyoglossus muscle. An osseous depression on the internal side of the mandible represented the external wall of the sublingual gland space. The superior wall is clinically the most significant. It consists of the sublingual mucosa and a sublingual fold. This wall represents a main surgical access to the gland. In edentulous mandibles this mucous fold may be at the level of the upper mandibular border which may hinder the use of the lower dental prosthesis.

Humans↗
PubMed1984

[Comparative study of concentrated blood derivatives of factor VIII].

The work presents results of the investigations of blood derivatives--F VIII concentrates: commercial cryoprecipitate, concentrate of intermediary purity and derivatives of high purity: Kriobulin--Immuno, Octobulin--Landerlan, Profilate--Alfa, Factor VIII--Behring, Hemofil--Hyland, Factorate--Armour Pharma, AHF--Kaote Cutter. The following parameters were investigated: VIII: C, VIIIR: Ag, total protein, protein electrophoresis, IgG, IgA and IgM immunoglobulins and anti-A and anti-B isoagglutinins. All derivatives except cyroprecipitate have considerably higher VIIIR: RAg value compared with VIII: C, which indicated inactivation of labile VIII: C component during concentrate preparation. Specific activity varied depending on purity of preparations, but ranged from 1,72 to 22. High isoagglutinin titer of anti-A was noted in preparations of high purity, as well as the presence of immunoglobulins. Despite considerable differences in vitro, all concentrated derivatives F VIII have similar immediate clinical effect and recovery from 0,87 to 1,36. All results indicate that new ways of derivative F VIII purification should be found with lower degree of contamination of other plasma proteins and less risk of hepatitis virus transmission. When certain indications are recognized, cryoprecipitate produced in our country in all blood transfusion services should be used.

Factor VIII↗
PubMed1980

[Physiologic values of coagulation factors in newborn infants].

Hemorrhagic tendencies are frequently seen in the neonatal period. From the practical point of view, recognition of physiologic deficiencies of coagulation factors and hemostasis is essential, for the differential diagnosis of hemorrhagic syndromes and adequate treatment. Values of coagulation factors in the newborn and comparison of our results and the results of other authors are presented. It seems that there are no essential changes in hemostasis of term infant, but many coagulation factors exhibit deficient clotting activity as like vitamin K-dependent factors (II, VII, IX, X). Values of fibrinogen, F. XI, XII, XIII are decreased. Those factors which physiologically low in the term infant reach normal adult levels in a few weeks, with the exception of factors IX and XI which may require several months to reach normal levels. In the same time authors presented the results of coagulation factors in mothers during delivery and term infants, to explain the nature of the disorders. For the investigation of these physiological defects, screening tests can be used.

Blood Coagulation Factors↗
PubMed1978

[Transfusion of leukocytes and platelets in the treatment of acute leukemia].

Supportive therapy of concentrated leukocytes and platelets has no obvious significance. In the paper authors presented the methods of separation of concentrated leukocytes and platelets, investigation of number and functional abilities of preserved leukocytes and platelets as well as the monitoring of the transfusion effect in the patients with acute myeloblastic leukemia. Special attention was paid to the separation of blood cells by the cell centrifuge with continuous flow. Side effects after leukocytes and platelet transfusion was monitored -- occurence of the sensibilization to the HL-A antigens. For the detection of HL-A antibodies two-stage microlymphocytotoxic test was used for the investigation of patient's serum; for the application of leukocyte and platelet transfusion we used cross-match test between donor's lymphocytes and patient's serum in progressive dilution. In the paper authors discussed the correlation between the appearance of HL-A antibodies and the number of given transfusions.

Blood Transfusion↗
PubMed1977

[Diagnosis of von Willebrand's disease].

Diagnosis and differential diagnosis of von Willebrand's disease was a special problem. Criteria up to date: prolonged bleeding time, reduced platelet adhesiveness, decreased F. VIII coagulant activity, as well as a particularly behaviour after the infusion of F. VIII, were not sufficient to differentiatie this disease from other congenital disorder of F. VIII. Recent investigations, introducing the immunological methods for determination of F. VIII--related antigen, as well as the investigation of ristocetin induced platelet aggregation, give the new approach in the diagnosis of von Willebrand's disease. Authors presented preliminary results of investigations of F. VIII--related antigen in the patients with von Willebrand's disease, as well as the results of investigation of the patients with hemophilia A and normal subjects, as a control group.

Adult↗
PubMed1977

[Immunoelectrophoretic method for the determination of factor VIII-related antigens].

Immunological examination of F VIII related antigen gave some new information on the nature of congenital defects of F VIII, in haemophilia A and von Willenrand's disease. Besides classic method in diagnostics of von Willebrand's disease, the determination of F VIII related antigen can be used as a diagnostic criterium in distinguishing von Willebrand's disease from some mild forms of haemophilis, as well as in detection of haemophilia carrier. In addition, the study on the relationship of immunological value of F VIII related antigen and biological activity of F VIII offers more data on the possibility of detection of so-called "hypercoagulability" and states proceeding thrombosis. The method for determination of F VIII related antigen (Rocket electrophoresis--Laurel) as well as the values of F VIII in health persons of our population is described in this paper.

Antigens↗
PubMed1976

[Concentrated antihemophilic globulin in the treatment of hemorrhagic syndromes].

The author presented the general informations on the preparation of the Factor VIII and Factor IX concentrates, on their use and side effects. Special attention was paid to the resolutions of the Scientific group on the Inherited Blood Clotting Disorders, in the meeting of the World Health Organization, which was held in Geneva, 1972.

Afibrinogenemia↗
PubMed1976

[Substitution therapy in the treatment of acute leukoses].

In the treatment of acute leukoses, from the first onset of the disease till the occurrence of the first remission, as well as in the course of intesive hemiotherapy, the substitution therapy by blood derivatives has the great importance. Anaemia, granulocytopenia, hypoproteinaemia and hemorrhagic syndroms, caused by thrombocytopenia, liver diseases and disseminated intravascular coagulation, are the most frequent disorders requiring the substitution therapy. Authors presented the advantages of the substitution therapy by blood derivatives upon the whole blood.

Acute Disease↗
PubMed1975

[Experiences at the Blood Transfusion Center of the Socialist Republic of Serbia in providing aimed transfusions].

The development of modern medicine causes the more and more needs of blood in providing the complete health care of the patients. The increased need can be satisfied only by the rational use of blood on the principle of selective transfusions. In this work our present possibilities are given, in the separations of certain blood components, their good and bad effects, as well as the indications for use in some pathological states.

Blood Platelets↗