Biomedical subjects
Publications and source records attributed to V D Labhasetwar.
Gelatin and methylcellulose microcapsules with and without sulphadiazine were compressed into compacts. The dielectric constant of these compacts was measured at regular intervals during ageing at 45 degrees C. An initial sharp fall in dielectric constant is followed by a progressive increase. Dielectric constant could be a parameter to study the changes occurring in microcapsules during ageing.
Shellac esters were prepared by heating shellac with glycerol and intermediate reaction products were withdrawn. Salicyclic acid granules were encapsulated using a 20 per cent w/v alcoholic solution of shellac and shellac esters. The coated microcapsules were evaluated for moisture absorption, flow properties, and dissolution studies. The drug release from coated granules was seen to depend upon the acid value of the esters. Results indicate that shellac esters could be better encapsulating material than shellac in sustained release formulation.
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Gelatin, methylcellulose and agar microcapsules were prepared with and without suphadiazine. The zeta potential of these microcapsules was measured at regular intervals during ageing at 45 degrees C. An initial sharp rise in zeta potential is followed by a progressive decrease. Zeta potential could prove to be a useful parameter to study the changes occurring in the encapsulating material of microcapsules during ageing.