PubMed Health⌕ Search

Biomedical subjects

V D Novikov

Publications and source records attributed to V D Novikov.

At least 19 recordsLinked to original sources
PubMed2005

[Role of provisionality principle in realization of phylembryogeneses].

The analysis of histogenesis of skeletogenic tissues and of organogenesis of the mesonephros and metanephros in higher mammalian animals and man, is presented. The new conception of provisionality is formulated, according to which embryonic primordium and/or its derivatives possess a determined capacity to form, on its course to definitive state, temporary structures (tissues or organs), which fulfil the vital functions in the developing organism and modeling the mechanisms of development and formation of structural and functional units or the whole organ at the level of definitive morphological substrate. Provisionality is regarded as the universal principle in realization of of phylembryogeneses.

Animals↗
PubMed2005

[Morphological study of placenta and liver of pregnant rats in experimental endotoxicosis and after ceolite protection].

In 45 rats and 120 fetuses the protective effect of food, containing the additives of natural ceolites, on the outcome of pregnancy complicated by an acute experimental endotoxicosis, caused by hyperthermic challenge of the animals, was studied. Using gravimetric, histological, histochemical, electron microscopical methods and monitoring the markers of endogenous intoxication, it was demonstrated that the consumption of ceolite additives contributed to the increase of resistance of the organism to the extremal challenge. Ceolite enteroprotection of acute endotoxicosis, caused by hyperthermic challenge of the pregnant rats, resulted in the increased survival of animals, lower embryonic losses, adaptive changes in placenta and maternal liver.

Animals↗
PubMed2004

[Structural organization of human yolk sac epithelium during first three months of intrauterine development].

Epithelium of the endodermal origin in the human yolk sac was studied at prenatal weeks 5-12. In the beginning of the period studied the epithelium was characterized by high volume density, distribution in the different zones of the organ and polymorphism. The highest secretory activity of epitheliocytes was observed at weeks 7-8 of intrauterine development. After this period, epithelium total volume density decreased, while the fraction of inner epithelial lining layer increased. The epithelium-lined cavities in the yolk sac wall shrinked and disappeared, and the volumes of the cells and nuclei decreased. These morphological changes of the epithelium are indicative of the loss of the organ basic functions already by the end of embryonic period of human development.

Embryonic Development↗
PubMed2002

[The assessment of structure-function interrelationship from the standpoint of functional systems].

One of the major methodological problems of morphology--the correlation of "structure" and "function" categories in normal anatomy and histology--is discussed. The issues of mobility of concepts concerning organization of functional systems, differon tissue organization, tissue classification including the special place of extraembryonic organs, are examined. The organizational matters associated with the introduction of a new speciality 03.00.25--histology, cytology, cell biology--and with the necessity of revision of the program of qualifying examination in philosophy for the candidate's degree in the field of histology, are discussed.

Histology↗
PubMed2000

[The structural manifestations of the adaptive mechanisms occurring in the villous placenta during gestosis].

Using morphometry, optic and structural analysis and immune histochemistry structural manifestations of adaptive mechanisms in placenta of hemo- and desmochorial type during gestation were studied. Signs of similarity and diversity of realization of adaptive mechanisms at tissue and cellular level were found. Reduction in placental barrier thickness and number of surface capillaries and also activation of trophoblastic elements genome relate to similar signs. Formation of terminal villi is a divergent adaptive mechanism in hemochorial placenta, while intensification of migration of main functionally active cells from trophoblast lining to mother tissue is those in desmochorial placenta.

Adaptation, Physiological↗
PubMed2000

[Changes in the parietal layer of the yolk sac of the rat in the 2nd half of pregnancy (a morphological and morphometric analysis)].

Parietal layer of the yolk sac was studied in rat on d 11-21 pregnancy, taking into consideration topographic peculiarities and regional differentiation. Epithelial cells of placental and obplacental zones differentiate asynchronously, but perform similar specific functions. Parietal layer of the yolk sac regulates selective transport of macromolecules to the embryo (or fetus) in placental region and entodermal sinus.

Animals↗
PubMed2000

[Morphological and functional characteristics of lymphocytes of mothers of children with Down syndrome].

Nuclear chromatine of peripheral blood lymphocytes was studied in 13 women with children suffering from Down's syndrome using optic structural computer analysis. In 12 cases significant increase of nuclear roundness coefficient was determined. Deformation coefficient was determined for heterochromatine structures in 8 cases. Integral optic density of nuclear chromatine was significantly decreased in 12 women. This indicates the reduction of felgen-positive material due to deficiency of its compact fraction (in 11 cases). The activity of lymphocyte cytoplasmic lactate, alpha-glycerophosphate and succinate dehydrogenases (SDG) was studied morphocytochemically in 5 women who had children with the disease. High activity of mitochondrial SDG was determined in all cases which probably indicates disorders in lymphocyte energy state. This is one of the reasons for retention of risk pregnancy. Further research in this area may serve as a base for complete cytoanalysis in order to distinguish risk groups among women including primagravida for consequent determination of embryonal karyotype.

Adult↗
PubMed1997

[Changes in the placenta of the elk Alces alces L. during pregnancy (morphometric research)].

Elk placentomes were studied during different stages of pregnancy using morphometry and optico-structural computerised analysis. Histological sections and smears from the surface of placentome section were made for that. Placentome were obtained from animals subjected to legal shooting in hunting districts of Novosibirsk. The attention was focused on the examination of cellular elements that constitute a trophoblastic lining and on distribution of capillaries maximally close to trophoblast in chorion villi. Diplokaryocytes are the predominant cellular population among the giant trophoblastic cells. The process of trophoblastic elements migration oriented to maternal organism tissues was described during the entire gestation period since month 3 to 8. Small placentome appearance on month 7 of pregnancy is considered for the manifestation of placental accessory compartments formation within the period of more intensive growth of the fetus body weight.

Animals↗
PubMed1992

[The photometric characteristics of the nuclei of normal human and bovine lymphocytes and in pathology].

Chromatin structure has been studied with a method of optico-structural machine analysis for interphase nuclei of peripheral blood lymphocytes in healthy donors, a girl with the Shereshevskiĭ-Turner syndrome (45, XO) and her parents, and for peripheral blood lymphocytes of a cow, Bos taurus L., in the last trimester on the background of preeclamptic syndrome and with normal cow pregnancy of compared terms. A significant change was revealed both in human heteroploidy and in developing preeclamptic syndrome in animals as concerns such indexes as the nucleus area, integral optical density, the amount and area of condensed, decondensed chromatin. The profile of histograms, according to the given parameters, is distinctly changing. The analysis based on constructing a two-measured field in the given coordinate system showed changes in the lymphatic population structure with the increase in the rate of "heavy", enriched DNA cells.

Animals↗
PubMed1988

[Trophoblast in villi of the early human chorion according to the data of optico-structural analysis and electron microscopy].

Presence of nuclei with tetraploid content of DNA in syncytiotrophoblast of the early chorion has been demonstrated. Before 8 weeks of pregnancy their content makes 31% and then it drops up to 26%. At this age certain severe changes are revealed in texture characteristics of the nucleus--asymmetry and kurtosis of chromatin distribution. Possible pathways of ultrastructural rearrangements in epithelium of the early chorion are discussed.

Chorionic Villi↗