A synthetic polypeptide with a compact structure and its self-organization.
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Binding Sites↗
Biomedical subjects
V D Pautov
Publications and source records attributed to V D Pautov.
[The role of small-scale movement in the protein globule in intensifying the electron interactions of photoactive groups].
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Electrons↗
[Proteins with varied levels of photoactive groups of anthracene structure for studying their structural organization by various luminescence methods].
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Anthracyclines↗
[Conjugates of pancreatic ribonuclease and ligand-free human serum albumin].
Conjugates of pancreatic RNase and ligand-free human serum albumin (LFHSA) have been obtained. The number of hydrophobic binding sites both for initial HSA and LFHSA has been determined by the polarised luminescence method. Interaction between RNase and HSA involves additional electrovalent linkage. Unlike initial enzyme, conjugates exhibit activity toward double-strand RNA. After intravenous injection, transferase activity of unmodified enzyme remains in the blood during 20 min., whereas 30-40% of this activity is detected at the fourth day after administration of RNase conjugates. A single dose administration of LFHSA-RNAse conjugates exhibited high antiviral activity in mice, infected with influenza A and influenza B viruses.
Animals↗
[Structural-dynamic and functional properties of native and modified streptokinase].
The process of streptokinase modification by a polymer and the dynamics of protein molecules and the polymer in a protein-polymer (dialdehyde dextran, DAD) conjugate were studied with the aid of luminescent methods. Conclusions were drawn on the structure of the protein-DAD conjugate and the selection of optimum conditions for the preparation of modified streptokinase. It is shown that modified streptokinase is more stable to the action of denaturating agents. The interaction between streptokinase and plasminogen activated by it and changes in the streptokinase-plasminogen complex for modified streptokinase were detected.
Dextrans↗