Biomedical subjects
Publications and source records attributed to V D Rozenberg.
Description of a rare hereditary heart disease in a newborn (heart-hand symptom complex: changes of the shape and structure of a forearm with the absence of thumb and finger V plus atrial septal defect) is presented. The combined effect of genetic and environmental influences is regarded as a cause of the syndrome.
Two genetically associated observations of the familial cardiomyopathy in a 34-year-old father and 2-day-old son are described. Verification of the lesions is performed by means of macro-and microscopic analysis including the post-mortem contrast cardioventriculography and histotopographic investigation. Specific changes in the interventricular septum and left ventricle are found in both cases as well as asymmetric hypertrophy and elimination of the cavity of the left ventricle in both father and son.
The modification consists of the replacement of alcohols of increasing concentration by glycerols. This results in a shortening of tissue treatment, improvement of the preparation quality due to the full exclusion of the alcoholic tissue shrinkage and cell structure deformation as well as alcohol saving.
The results of the ultrasound use for the acceleration of histologic tissue processing are analyzed. Main mechanisms of the ultrasound effects on tissues as well as a method of the UTP-1 apparatus use for the acceleration of the paraffin embedding are presented. The simplicity of this method, saving the chemicals without a quality loss, a possibility of tissue processing through paraffin and celloidin as well as having histological slides 5-6 hours after cutting material allow one to recommend the above apparatus for the practical use.
The modification of the three-colour tissue staining (haematoxylin, eosin, light green) facilitating effective combination of haematoxylin and eosin staining with that by Van-Gieson is described. The simplicity and rapidity of this technique, its efficiency and the possibility to use frozen, celloidin and paraffin sections allow one to recommend it for the pathohistological practice.
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The author presents a retrospective and complex pathomorphological analysis in 152 autopsy cases. Death was caused by different forms of cardiomyopathies. Aim of the study to reveal the frequency of pathology, causes and mechanisms of death. The prevailing frequency of dilated cardiomyopathy was established--106 cases, 0.88%. Hypertrophic and restrictive forms--32 (0.27%) and 14 (0.12%) of cases. the dominating cause of death (42.7%) was chronic cardiac failure. Other death causes were as follows: thrombosis and embolism--17.8%; arrhythmic collapse--13.2%; ventricular fibrillation--9.9%; acute left-ventricular failure--8.6%; real cardiogenic shock--7.8% of all cases of cardiomyopathies.
A complex study was made of 20 hearts from patients who had died from hypertrophic cardiomyopathy and 20 matched control hearts with a view to detecting changes of the ventricular septum and to ascertaining the significance of echocardiographic diagnostic information. Postmortem cardioventriculography, coronarography, volume-mass and planimetric cardiometry, target histopographic techniques, were applied. Various ventricular septum hypertrophies, such as even, midventricular, wave-line, midapical and apical, were identified. A complete coincidence was found between the cardiographic and pathomorphological diagnostic findings in 6 (30%) cases, a partial one was seen in 7 (35%), and incoincidence was also observed in 7 (35%) cases. The paper provides the major factors underlying echopathomorphological dissociations.
Disorders of heart rhythm and conduction were characterized clinically and by electrocardiography in 82 patients with dilated and hypertrophic cardiomyopathies. Based on an analysis of blood lymphocyte cytochemistry energy-deficient conditions of the myocardium were identified in the patients examined. In order to correct the metabolic shifts in the myocardium, use was made of a coenzymic medicamentous complex including pyridoxalphosphate, cobamamide and phosphadene. The complex indicated was shown to potentiate the action of antiarrhythmic agents employed in the treatment of idiopathic cardiomyopathies.
A complex pathomorphological examination of 46 hearts from subjects who had died of dilated (34 cases) and hypertrophic (12 cases) cardiomyopathies was performed to reveal the changes occurred in the vascular bed. For this, post-mortem coronary angiography, routine anatomic method developed by the WHO, morphometric, histological, and statistical methods were applied. In dilated cardiomyopathy, there were dilatory manifestations in the coronary arteries and vessels of microcirculation along with increased volumetric density of ventricular vascularization. Hypertrophic cardiomyopathy was characterized by a specific rearrangement in the presence of the "intensive coronarogram symptom", microvascular plexus, myocardial muscular bridges, and heterogeneous manifestations of microvessels with decreased capillarization.
A detailed study was made of the hearts from 52 subjects who had died from three types of cardiomyopathy (dilated, hypertrophic, and restrictive) and 54 death victims who comprised control groups. Postmortem contrast cardioventriculography and volume-weight cardiometry were applied. The characteristic cardioventriculographic differential and diagnostic criteria were established. Dilated cardiomyopathy was characterized by a drastic increase in the ventricular volumes along with changes in the type and arrangement of the interventricular septum. Hypertrophic cardiomyopathy showed forms of septal hypertrophy with diminished left ventricular cavity taking a definite form. Restrictive cardiomyopathy was distinguished by lower ventricular volumes with signs of obliteration, changes in the parietal endocardium and events of calcification.
A study of 50 hearts from patients who died of dilated cardiomyopathy and 16 control cases is presented. It included evaluation of the character of hypertrophy and dilatation, state of the volume and ventricular cavities as well as the interventricular septum, changes of the coronary system and blood microcirculatory bed of the heart. Methods used were: postmortal contrast cardioventriculography and coronarography, intravascular impregnation and impregnation of frozen sections of the myocardium with silver nitrate. The authors singled out a triad of signs possessing a high degree of pathognomonicity and including pronounced dilatational manifestation on the part of the cardiac ventricles, coronary arteries and blood circulatory bed.
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UNLABELLED: A complex pathomorphological study was carried out of 80 hearts from patients who died of cardiosclerosis with marked heart rhythm disorders and 20 control cases with the purpose of assessment of the criteria of diagnosis of the arrhythmogenic heart. METHODS USED: postmortal coronarography and cardioventriculography, microdissection, WHO standard anatomical method, morphometric histological, histochemical and histotopographic methods. The author established pathomorphological criteria of diagnosis of the arrhythmogenic heart including a separate construction with prevailing changes of the right ventricle, fibro- and lipomatosis of the myocardium, extensive coronary obstruction forming ischemia foci in the conduction system zones which are the site of formation of arrhythmogenic substances.
A pathomorphological study included hearts of 52 patients who died of various forms of cardiomyopathy, 10 hearts of subjects who died of chance causes (control) and 30 hearts in 3 groups of comparison for revealing changes in the interventricular septum in the dilatation, hypertrophic and restrictive forms of cardiomyopathy. Use was made of postmortem coronarography and cardioventriculography, the WHO standard anatomical method, histological and histochemical methods and separate weighing of cardiac portions. A complicated structure of the interventricular septum pathognomonic for each form of cardiomyopathy was revealed which had an influence on the intracardiac hemodynamics.
The authors studied 14 hearts of patients who died of restrictive cardiomyopathy with purpose of finding distinct diagnostic criteria. Modern clinical and morphological methods were used. Characteristic changes in the ventricles were noted. Pathognomonic volumetric and planimetric cardiometric criteria were found. The endomyocardium showed a characteristic layer-like structure including loose, dense connective and granulation tissue with signs of calcification. The essence of the restriction syndrome in cardiomyopathy is defined.
Changes in cardiac angioarchitectonics were studied in 60 cases of sudden coronary death and in 20 controls by means of multiprojection, quantitative coronarography and WHO standard anatomic method. A significant rate (60%) of stenotic atherosclerotic and dilatational (40%) changes was revealed in 3 major coronary arteries. Rearrangement of collateral circulation with the development of myocardial hypervascularization signs was found in 53.3% of cases, with the formation of "new" coronary path ways in 26.7%, and complete bypass blood flow in 20% of cases. Frequent stenoses of the anterior branch of the interventricular septum and sinus node artery were revealed, as well as intramural localization of the anterior interventricular artery due to myocardial muscular bridges, decrease of vascularization density in the left ventricular posterior wall myocardium and septum.