[Endothelin-1 level in the complicated course of myocardial infarction].
In the uncomplicated course of myocardial infarction (MI), the level of endothelin-1 (ET-1) comes to be increased beginning from day 1 and remains the same during the acute phase of the disease and gets decreased during the subacute phase. In MI presenting with parietal thrombosis, left ventricular aneurism, the level of ET-1 increases during the first period of 24 hours, increasing further toward the end of the acute phase, there being no decrease in the subacute phase. In MI presenting with pericardial effusion, an increase in the level of ET-1 is seen during the first period of 24 hours of the disease with no rise being recordable in peptide concentration during the acute and subacute phases. There is a positive correlation between the level of ET-1 and size of the heart cavities in the systole and diastole, pressure in the pulmonary artery, and a negative one with indices for the systolic function.