[Microbial genetics and medicine].
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Biomedical subjects
Publications and source records attributed to V D Timakov.
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Two important problems of current medical microbiology are discussed in this paper: 1) a change of etiological structure of infectious morbidity-elevation of the incidence of infections caused by conditioned pathogenic causative agents, and 2) postvaccinal complications. In the light of these problems the tasks of microbiological investigations for the immediate future are discussed. Tasks and prospects of study of the molecular structure of the pathogenicity factors of importance for the creation of chemical vaccines and genetic investigations which would provide construction of strains and preparations useful in practice are formulated.
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Stable L-forms were for the first time obtained under the effect of tetracycline on the Mec thnikov vibrio and NAG vibrio. The process of conversion of the L-forms under the effect of tetracycline was the same as under the action of penicilline. Three types of the L-forms were obtained: stable tetracycline-resistant L-forms, stable tetracyclin-superresistant and tetracycline-dependent L-forms. Under the reversion of the unstable L-forms strains with a typical complex of biological properties and atypical revertants were obtained.
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