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Biomedical subjects

V D Zakharychev

Publications and source records attributed to V D Zakharychev.

At least 19 recordsLinked to original sources
PubMed1991

[Changes in cytotoxicity of natural killer cells and level of large granule-containing lymphocytes in patients with lung cancer under the effects of cryosurgery].

The parallel study of the content of large granule-containing lymphocytes (LGL) and natural killer activity (NKA) in donors, patients with benign tumors in the lungs and bronchial or pulmonary cancer in operative intervention and combined cryosurgical treatment was carried out. The stimulating effect of cryodestruction of malignant tumors with their subsequent spontaneous thawing on LGL content and NKA in patients was established. Administration of prodigiosan immunomodulator contributed to increase in natural resistance of an organism of the patients. The positive correlation of NKA and LGL content was noted.

Bronchial Neoplasms↗
PubMed1989

[Prognostic factors in operable non-small cell cancer of the lungs].

The influence of different factors on prognosis after radical operations in 316 patients with non-small cell peripheral pulmonary cancer was studied. In N0, the 3-year survival of the patients was 51.2%, 5-year--34.7%. In N1, the 3-year survival was 23.9%, in squamous cell cancer--40.6%, glandular--10.2%, 5-year survival--12.3%. The reduction of survival in N2 is significant in glandular, and in squamous cell cancer as well. In N2, the 3-year survival was 4.8%, 5-year survival was absent. It should be considered that in patients with stage T3N2 peripheral pulmonary cancer, there are subclinical metastases. The operation in this case is not a method for radical treatment. The influence of a tumor size on the prognosis is manifested in T3. Histologic structure in non-small cell cancer influences prognosis only at the stage T2N1 (in glandular cancer, the survival is significantly worse). The degree of differentiation in squamous cell cancer influences the prognosis. Tumor spreading to the adjacent structures makes prognosis worse, but the surgical treatment in such a case is justified.

Adenocarcinoma↗
PubMed1989

[The effect of combination cryosurgical treatment on the natural resistance of patients with cancer of the lung].

By the method of measuring the percentage and absolute content of the large granule-containing lymphocytes in the peripheral blood of the healthy subjects, in pulmonary cancer and benign process in the lungs at admission, just before the operation, at day 1 and at days 13-14 after the operative intervention and combined cryosurgical treatment, the data about the stimulating effect of cryodestruction on the natural resistance of an organism of the patients were obtained.

Adult↗
PubMed1979

[Diagnosis and treatment of mediastinal teratomas].

Among 221 operated patients with primary tumors and cysts of the mediastinum teratomas were observed in 54 (24.4%). The diagnosis of mediastinal teratodermoids should be complex. Clinically in benign teratomas the localization and character of the process were determined precisely in 94%, histogenesis--in 35%, in malignant teratomas--the proper localization was determined in 90%, the tumor character--in 78%, histogenesis--in 26%. For malignant tumors the combination therapy with intensive telegamma therapy prior to and after surgery was employed. Resectability in malignant teratomas made 73%, the postoperative mortality--in 5.5%. A five-year survival following radical surgery in patients with malignant teratoma was 37%. In inoperable teratoblastomas it seems rational to use intensive split course telegamma therapy with a total focal dosage of 5,500-6,500 rad.

Adult↗
PubMed1975

[Cytomorphologic characteristics of malignant tumors of the mediastinum].

The cytomorphological characteristics of most frequently encountered malignant tumors of the mediastinum are described. Needle biopsy specimens of mediastinal neoplasms were examined in 152 patients, 77 of them (56,2%) having malignant tumors. In 118 cases pathomorphological study of the intraoperative or biopsy findings was performed. The correct positive cytological conclusion was made in 85 (56.2%) patients negative -- in 31 (20.3%), doubtful -- in 33 (21.7%), pseudopositive -- in 3 (1.9%).

Adolescent↗