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V Davison

Publications and source records attributed to V Davison.

5 recordsLinked to original sources

Amniotic fluid acetylcholinesterase activity and alpha-fetoprotein in chromosomal anomalies and neural tube defects.

Measurement of alpha-fetoprotein concentration and acetylcholinesterase activity in amniotic fluid can be used to identify chromosomal defects as well as neural tube defects. In seven cases of trisomy 21 and one case of partial trisomy 3, alpha-fetoprotein concentrations were below the reference range but values for acetylcholinesterase activity were normal for the appropriate gestational age. One case of trisomy 13 had an increase in acetylcholinesterase activity and normal alpha-fetoprotein concentration.

Acetylcholinesterase

Amniotic fluid gamma-glutamyl transferase activity in trisomy 21 and neural tube defects.

The amniotic fluid gamma-glutamyl transferase (gamma GT) has been measured in normal pregnancies (n = 128), six pregnancies associated with trisomy 21 and 12 pregnancies involving a foetus with a neural tube defect. In normal pregnancies, the amniotic fluid gamma GT activity falls during the second trimester, the level at 20 wk being 60% of that at 14 wk. In the six cases of trisomy 21 and 8 of the 12 cases with neural tube defects, the gamma GT levels were below the 95% confidence limit.

Amniotic Fluid