Drugs influencing cognitive function.
Explore the source record for details and available documents.
Alzheimer Disease↗
Biomedical subjects
V Devi
Publications and source records attributed to V Devi.
Haplotypes in tribal Indians bearing the sickle gene: evidence for the unicentric origin of the beta S mutation and the unicentric origin of the tribal populations of India.
To determine the origin of sickle cell anemia (SS) in India, we analyzed haplotypes of the beta gene cluster in beta S-carrying individuals belonging to tribal populations living in the Nilgiris region of southern India and complemented the available data on tribes of east-central India. We found that in the Nilgiris tribes chromosomes bearing the beta S gene are linked in 91% of the cases to the "Asian" (Arab-Indian) haplotype (although 25% of the haplotypes had the epsilon polymorphic site negative, making the 5' portion of the haplotype identical with the African Senegal haplotype). These XmnI (+) chromosomes were associated with high G gamma expression (67.2 +/- 5.9%) and a high percentage of Hb F (15.5 +/- 7.9%; range, 6-25.3%). We have similar findings for tribal groups from west-central India (Gujarat). In east-central India we have confirmed the data of others, finding the same haplotype linked to beta S in tribes living in the east (Orissa, Andhra Pradesh). We conclude that the beta S gene in presently isolated and disperse tribal populations in India is associated with one predominant typical haplotype, suggesting a unicentric origin of the mutation in India. In addition, this finding implies a unicentric origin of the tribal populations themselves: The gene must have arisen and spread before tribal dispersion. Furthermore, we find extremely high frequencies of the (-alpha) haplotype in the Nilgiris (0.89) and in Gujarat (0.95). The beta S gene linkage to a high Hb F-expressing haplotype and the high incidence of alpha-thalassemia predict a mild phenotypical expression of sickle cell anemia in India.
Anemia, Sickle Cell↗
Giant cervical herniation of an apical pulmonary bulla.
A 60-year-old woman had a giant air cyst in the right side of the neck, which arose from the apex of the right lung. We are unable to find a similar case report in literature.
Female↗
Caudate atrophy in irreversible tardive dyskinesia (a pneumoencephalographic study).
Pneumoencephalography done under standard conditions on 5 patients with tardive dyskinesia and 3 matched controls revealed evidence of caudate atrophy in 3 of the dyskinetic patients. The same 3 patients proved refractory to treatment of their dyskinesia. It is concluded that tardive dyskinesia is a heterogenous entity with some patients having irreversible dyskinesia and exhibiting radiologically demonstrable damage.
Adult↗