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V Dimov

Publications and source records attributed to V Dimov.

35 records · Page 2Linked to original sources
PubMed1979

Plasma levels of 15 (S) 15-methyl-PGF 2 alpha-methyl ester following vaginal administration for induction of abortion in women.

A single suppository containing 3.0 mg 15 (S)15-methyl-PGF2 alpha-methyl ester was administered vaginally in women to terminate mid-trimester pregnancy. Plasma levels of the drug (both methyl ester and free acid forms) were measured at different time intervals using deuterated carriers and gas chromatography-mass-spectrometry. 15(S)15-methyl PGF2 alpha (sum of methyl ester + free acid) was found to have a mean value of 1166 pg/ml plasma at 3 hrs after administration of the suppository. The mean levels were subsequently found to be maintained in the range of 1000 pg/ml. Preliminary studies showed that unlike the successfully aborted women, in those who did not abort within 30 hrs with this suppository, the plasma levels of the drug were not maintained for a sufficiently long time. The episodes of side effects, body surface area and the induction-abortion interval in relation to the plasma levels are discussed.

Abortion, Induced↗
PubMedDate not supplied

[Association between phakomatosis and neoplasia in children pathology. IV Pediatric Clinic experience].

The risk to developing a neoplasm is increased when associated to a patient phakomatosis (Recklinghausen neurofibromatosis, Bourneville's tuberous sclerosis). We analysed 6 cases with phakomatosis and tumours, admitted in the Department of Oncopediatry, between 1993-1998; five of these children had neurofibromatosis and one Bourneville's disease. The associated tumours were hematologic malignancies (juvenile myeloid chronic leukemia) and solid tumors (rhabdomyosarcoma, hepatic carcinoma, CNS tumour, NHL optic glioma). The diagnosis was confirmed by microscopic examination of the bioptic material in all cases. Tumoral staging was performed by clinics, biology and imagistic investigations. All cases had extensive and aggressive tumours at the moment of diagnosis, We noticed a poor response and an early relapse after chemotherapy. A special follow-up and a different management has to be established for the patients with phakomatosis, in order to have a good oncological prophylaxis.

Adolescent↗
PubMedDate not supplied

Metabolism of prostaglandin F2 alpha in sheep.

The metabolism of prostaglandin F2 alpha (PGF2 alpha) in ewes was studied after im injection of 9 beta-3H-labeled PGF2 alpha. About 75% of injected radioactivity was excreted in urine within 6 hr, whereas less than 1% was excreted in the milk over 3 days. Most identified urinary metabolites were formed through well known reactions involving oxidation of the hydroxyl group at carbon 15, saturation of double bonds, and oxidation of both carbon chains. However, some metabolites underwent more extensive oxidation of the carbon chain than had been seen before in other species. This might have taken place through catabolic activity of the gastrointestinal microflora followed by reabsorption into the circulation.

Animals↗
PubMedDate not supplied

Metabolism of 16, 16-dimethyl-trans-delta 2-prostaglandin E1 methyl ester (ONO-802) following intravenous and vaginal administration to pregnant women.

Following iv and vaginal administration of (5,6-3H2)-ONO-802 (5,6-3H2-16, 16-dimethyl-trans-delta 2-prostaglandin E1 methyl ester) the appearance of radiolabeled compounds in plasma and urine were studied in early pregnant patients. Following iv administration, ONO-802 was rapidly hydrolyzed to the free acid which disappeared from plasma with an approximate half-life of 10-15 min. About 50% of the injected amount of compound was excreted in urine during the first 24 hr after injection. The structures of 16 urinary metabolites were determined. These data demonstrated that, following hydrolysis of ONO-802 to the free acid, the latter can undergo beta- and omega-oxidation like other prostaglandin analogs where enzymatic attack of the 15-hydroxyl group has been blocked. Some of the metabolites were excreted as conjugates (sulfates, glucuronides?) and, in two, the oxo group at C-9 had been reduced to a hydroxyl. Following vaginal administration of ONO-802 (1 mg, 60 microCi) in suppository form, radioactivity corresponding to 100-200 pg/ml of ONO-802 equivalents was found in plasma. The profile of metabolites in urine was qualitatively very similar to that after iv injection of (5,6-3H2)-ONO-802. Based on the data on excretion of metabolites in urine it was calculated that 12-28% of the dose administered vaginally was resorbed into the circulation.

Alprostadil↗
PubMedDate not supplied

[Superacute extradural hematoma].

After a survey of data in the literature the authors have used four criteria for the identification of the supraacute extradural hematoma:--an interval of maximum two hours between the occurence of the trauma and the performance of the intervention or exitus;--a severe cerebral syndrome with primary brutal coma, or coma that has developed in the above-mentioned interval;--the discovery during intervention of a "developing" hematoma, mostly as fluid, and the identification of the source of haemorrhage;--persistent cerebro-ventricular collapse after evacuation of the hematoma, that makes necessary the application of operative procedures for achieving recovery. Two of the 5 observations of the authors are presented, both in males, aged 22 and 73 years respectively, in whom surgery was performed in an interval of less than two hours. All the patients were comatose when the intervention was carried out, and 3 of them had a temporal fracture. The diagnosis was made by angiography. During surgery a fluid extradural hematoma was found, and the source of the haemorrhage was identified in three of them as a major branch of the median meningeal artery. One death was recorded due to recidive of extra-dural hematoma, associated with cerebral contusion and cerebral edema. In all the five patients the authors found cerebro-ventricular collapse that was recovered by introduction of physiologic saline and air through the lumbar route during the intervention.

Acute Disease↗