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Biomedical subjects

V Doctor

Publications and source records attributed to V Doctor.

7 recordsLinked to original sources
PubMed1999

Distribution of haplotypes from a chromosome 21 region distinguishes multiple prehistoric human migrations.

Despite mounting genetic evidence implicating a recent origin of modern humans, the elucidation of early migratory gene-flow episodes remains incomplete. Geographic distribution of haplotypes may show traces of ancestral migrations. However, such evolutionary signatures can be erased easily by recombination and mutational perturbations. A 565-bp chromosome 21 region near the MX1 gene, which contains nine sites frequently polymorphic in human populations, has been found. It is unaffected by recombination and recurrent mutation and thus reflects only migratory history, genetic drift, and possibly selection. Geographic distribution of contemporary haplotypes implies distinctive prehistoric human migrations: one to Oceania, one to Asia and subsequently to America, and a third one predominantly to Europe. The findings with chromosome 21 are confirmed by independent evidence from a Y chromosome phylogeny. Loci of this type will help to decipher the evolutionary history of modern humans.

Animals↗
PubMed1996

Prognostic value of argyrophylic nucleolar organiser regions (AgNORs) in breast lesions.

A total of 200 breast tissues which included 5 normals, 55 benign and 140 malignant lesions were stained for Argyrophilic Nucleolar Organiser Regions (AGNORs). A comparison of the AGNOR values with histologic variables, viz., tumor type, size nuclear grade, desmoplasia, elastosis, lymph node metastasis and Oestrogen and Progesterone Receptor (ER/PR) status was carried out in malignant lesions. AGNOR values could sharply distinguish benign from malignant lesions. Among the malignant lesions, an attempt to determine the value of AGNOR count in prognostication was made. AGNOR counts correlated with tumor size, mitoses and desmoplasia. ER/PgR negative tumors showed a tendency for high NOR counts, but lymph node metastasis, which is considered one of the most reliable prognostic indicators, did not concur with AGNOR counts in our study. These results indicate that AGNOR counts can not be used as a sole independent marker in breast cancer prognostication.

Breast Diseases↗
PubMed1983

Single endometrial aspiration for determination of ovulation.

The possibility of utilizing a single endometrial aspiration for the determination of ovulation was explored and compared with endometrial histology, serial vaginal cytology and plasma progesterone. A total of 180 women with normal, regular cycles and no pelvic pathologic conditions were studied. A correlation of 90.5% was observed between aspiration smears and histology. Vaginal cytology and histology agreed in 71.7% of the cases, while plasma progresterone and endometrial histology correlated in 95% of the women. Endometrial aspiration appeared to be an accurate, quick, inexpensive, convenient and a one-time method, which could be repeated in successive cycles without any patient discomfort.

Endometrium↗
PubMedDate not supplied

The endocervical smear as a simple and quick method for the determination of ovulation.

The endocervix undergoes cyclic changes in every menstrual cycle, as reflected by the rheologic properties of the cervical mucus. A study was therefore undertaken to establish whether there were any morphologic changes in the endocervical columnar cells, as seen in the endocervical smears, that could be correlated with ovulation and anovulation. An endocervical smear was collected in the luteal phase of the cycle from patients in whom an endometrial biopsy or D & C was being done as a part of an infertility investigation. A significant correlation was observed between the endocervical smear interpretation and the endometrial histology as to whether the cycle was ovulatory or anovulatory.

Adult↗
PubMedDate not supplied

Detection of ovulation by a single endometrial aspiration smear. A preliminary report.

An attempt was made to detect ovulation in 106 normally menstruating women by studying a single endometrial aspiration smear taken just before an endometrial biopsy or D & C on about day 24 +/- 2 of the menstrual cycle. The interpretation of the smears was compared with the histology, and a correlation was observed in 92% of the cases. It is therefore concluded that a single endometrial aspiration smear can be used to detect ovulation. It is an easy, quick, accurate and practical method and can be repeated as often as required.

Biopsy, Needle↗