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Biomedical subjects

V Dolenc

Publications and source records attributed to V Dolenc.

17 recordsLinked to original sources
PubMed2000

Cathepsin B and its inhibitor stefin A in brain tumors.

Cysteine protease cathepsin B (CatB) and its endogenous inhibitor stefin A (StA) play an important role in tumor progression. Increase of CatB expression and lower levels of its inhibitors were associated with tumor malignancy in brain tumors. In this study of 100 patients, CatB was localized by immunostaining to both, tumor and endothelial cells of primary brain tissue. Significant correlation with poor prognosis was found by univariate Cox's regression model. Intense overall immunostaining and immunostaining in endothelial cells alone were prognostic for survival (p=0.003 in both). When comparing CatB expression at mRNA level, we found considerable differences between center and periphery of a tumor as well as between different tumor samples. StA mRNA was only detected in benign, but not in malignant tissues. We suggest that screening of cysteine-protease genes expression can be applied in clinical prognosis of brain tumors.

Adult↗
PubMed1997

Conservative treatment of a traumatic direct low-flow carotid-cavernous sinus fistula: a case report.

A case of a 17-year-old boy presenting with a traumatic carotid-cavernous sinus fistula (CCSF), associated with an intracavernous pseudo-aneurysm, is reported. On angiography, the CCSF proved to be a direct and low-flow shunt. Conservative management was chosen and definitive closure of the fistula was obtained in two months by daily self-compression of the common carotid artery.

Accidents, Traffic↗
PubMed1983

Direct microsurgical intra-arterial procedures on ICA and MCA.

In ten patients operated on by the senior author, arteriotomy and reconstruction of the vessel wall with interrupted sutures were performed. Four patients underwent resection of an aneurysm, three thrombectomy, and one embolectomy, while in two patients an atherosclerotic plaque with thrombus was removed. Operation was undertaken to create normal vessel volume and restore and maintain adequate regional blood flow. These objectives were attained completely in seven cases and only partially in two cases, whereas in one patient we failed to meet the above requirements.

Adolescent↗
PubMed1983

Neurophysiological assessment of electrode placement in the spinal cord.

The use of neurophysiological techniques in addition to radiographic methods to determine the location of electrodes to be introduced into the epidural space for spinal cord stimulation is beneficial. Information on the distribution of paresthesias and muscle twitches provides an indication of the level and lateral location in relation to the midline of the spinal cord. For electrodes placed posteriorly, the threshold currents necessary for sensation are lower than those for muscle responses. Somatosensory evoked potentials resulting from epidural stimulation demonstrate effective depolarization of ascending structures. Evoked potentials recorded from the electrodes in response to peripheral nerve or spinal cord stimulation at a distant segment illustrate the possibility of activation of underlying generators of the spinal cord.

Brain Injuries↗
PubMed1983

Direct microsurgical repair of intracavernous vascular lesions.

Three patients with aneurysms of the internal carotid artery (ICA) situated in the cavernous sinus (CS), and four patients with traumatic carotid-cavernous fistulas (CCF's) were treated by direct surgical approach. Two aneurysms were clipped, whereas the third (a giant aneurysm) was resected and the wall of the ICA reconstructed using interrupted sutures. In two CCF's, the shunt was excluded during reconstruction of the ICA wall by suturing. In the remaining two patients with CCF's, the shunt was excluded by clipping. The CS was attacked directly using a combination of three different techniques: the pterional, the subtemporal, and the petrosal approach. The ICA in its whole course through the CS, as well as the third through the sixth cranial nerves, were exposed. No special measures, such as hypotension, hypothermia, extracorporeal circulation and cardiac arrest, or dehydration, were taken during surgery. The aim of the direct approach to the CS was to exclude the aneurysm and/or the CCF and preserve the ICA patency. In all seven cases operated on, the lesions were excluded without inflicting any additional damage to the third through sixth cranial nerves, and in five cases carotid patency was preserved.

Adult↗
PubMed1983

A tumor-simulating giant aneurysm of the vertebral artery. Case report.

A giant aneurysm of the left vertebral artery which was nearly completely thrombosed and very difficult to diagnose, was successfully treated by a complete surgical excision. The patient had been hospitalized eight times because of brief episodes of headache associated with neck stiffness, nausea, vomiting and numbness of the left hand. On the ninth admission, the diagnosis of a "tumour" involving the posterior fossa was established. At operation an aneurysm of the left vertebral artery was found and resected. At discharge, one week after surgery, the patient was free of neurologic deficits.

Adolescent↗
PubMed1982

Blood clot evacuation in aneurysm surgery in the acute stage (arguments pro and con).

In a series of 122 consecutive patients operated on by the senior author for rupture of an aneurysm the pterional approach was used in all but a few cases. A microsurgical technique was invariably utilized from opening to closing of the dura. Nearly half of our patients underwent surgery within the first week after subarachnoid haemorrhage (SAH). In the majority of cases operated on in the acute stage, a sizable subarachnoid blood clot was evacuated, mostly from the basal cisterns. The authors present their own experience in the field to show the superiority of the technically more demanding surgery carried out within the first days following SAH over other therapeutic procedures.

Acute Disease↗
PubMed1979

Microsurgical removal of large sphenoidal bone meningiomas.

At the Neurosurgical Department, University Medical Centre of Ljubljana, 10 extirpations of large meningiomas of the sphenoidal wing or tuberculum sellae were done during the period 1975-1978. Microsurgical technique, especially bipolar coagulation, made it possible to remove the tumourous mass from the cerebral tissue, cranial nerves, and arteries of the parasellar region. Out of 10 patients operated on, 2 died. The remainder, i.e. eight patients recovered. Only two showed any neurological signs.

Adult↗
PubMed1978

Treatment of fusiform aneurysms of the peripheral cerebral arteries. Report of two cases.

Two patients with fusiform aneurysms and at least one previous subarachnoid hemorrhage were treated by excision of the aneurysms and reconstruction of the arteries. The first case presented with two fusiform aneurysms, the larger of which involved the angular and the smaller one the temporal branch of the left middle cerebral artery (MCA). Both aneurysms were totally excised. The angular artery was reconstructed with a 1.5 cm long arterial graft taken from the left superficial temporal artery. Excision of the temporal aneurysm was followed by an end-to-end suture of the central and distal parts of the vessel. The second case had a fusiform aneurysms involving the temporal branch of the left MCA. The aneurysm was excised and an arterial graft 1 cm long cut from the superficial temporal artery was used in reconstruction of the affected vessel. In each case left carotid angiography was done 1 week postoperatively. In the first case the angiogram showed that the angular artery reconstructed with a graft was patent, whereas the temporal artery reconstructed without a graft was not visualized. In the second patient, whose temporal artery was reconstructed with a graft, angiography did not show the reconstructed artery. Left carotid angiography was repeated 1 year after the operation in both cases, and all the reconstructed vessels were well visualized.

Adult↗
PubMed1976

Nerve regeneration following primary repair.

In nine selected cases a primary nerve repair was done. In all these patients a special suture was used. Applying clinical and neurophysiological tests, regeneration of the motor and sensory nerve fibres was followed for two years. A remarkable difference in growth rates of sensory and motor nerve fibres was observed. The average rate of growth of sensory nerve fibres was 5 mm a day, and of motor nerve fibres it was 1.7 mm a day. At the end of a two years' interval after operation, good recovery from the initial muscular atrophy was observed in all but two cases. Function of previously denervated muscles was nearly normal. Discrimination of points 4-10 mm apart was possible. Normal terminal conduction times along motor nerve fibres were found in five cases. Slightly prolonged times were found in four. Calculated conduction velocities in sensory nerve fibres were half to three quarters of normal times. All patients resumed their previous occupations.

Axons↗
PubMed1976

Radial nerve lesions and their treatment.

Out of 332 patients with peripheral nerve injuries operated upon in our Department from the beginning of 1972 to the end of 1974, in only 30 were different types of radial nerve injury observed. In most cases radial nerve palsy was seen to be a secondary occurrence following fracture of the humerus or other types of injuries. Operation revealed 16 cases of fibrosis of the radial nerve and 14 of radial nerve defect. The longest defect was 20 cm long. In the first group of patients funiculolysis was performed, and in the second group funiculorrhaphy was performed using sural nerve grafts. With the exception of one case in the first group, good reinnervation of the previously denervated muscles was achieved, as well as the restoration of sensitivity in the affected skin areas.

Humans↗