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V Dorneanu

Publications and source records attributed to V Dorneanu.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Possible involvement of the L-arginine-nitric oxide pathway in the modulation of stress-induced analgesia.

The possible participation of nitric oxide (NO) in pain modulation and stress analgesia was studied in adult Wistar rats. Cerebral citruline as a coproduct of NO from L-arginine increased from the mean value 5.6 +/- 0.4 nM/mg.Pt. to 8.9 +/- 0.5 nM/mg.Pt. in acute restraint stress. In high doses (50 mg/kg body weight), intraperitoneal administration of L-arginine caused a small and transient decrease of the tail-flick latencies to the thermal stimulus, without significant changes of the stress analgesia induced by restraint stress. In animals pretreated with N-nitro-L-arginine methyl ester (NAME) a progressive increase of the latency time was obtained and the increased latencies induced by acute immobilization appeared significantly potentiated. These results offer new indirect evidence in favour of the modulatory role of NO in thermoalgesic sensitivity and stress-induced analgesia.

Animals↗
PubMedDate not supplied

[The production of nitro esters active at the level of the cardiovascular system].

In order to obtain new compounds with cardiovascular activity, some esters of nitric acid with ethanolamine were synthesised, using some aromatic acids, acexamic acid, the natural methylxanthines-theophylline and theobromine. The melting points, yields and solubility of the new compounds were determined, and the chemical structures were confirmed by elemental analysis C, H, N, and by spectral analysis in KBr.

Cardiovascular Agents↗
PubMedDate not supplied

Possible involvement of L-arginine-nitric oxide pathway in the modulation of stress-induced analgesia.

The possible participation of NO in the pain modulation and stress analgesia was studied in Wistar adult rats. Cerebral citruline as a stoichiometric coproduct of NO from L-arginine increased from the mean value 5.6 +/- 0.4 nM/mg.Pt. to 8.9 +/- 0.5 nM/mg.Pt. in acute immobilization stress. Intraperitoneal administration of L-arginine caused only in high doses (50 mg/kg body weight) a small transient decrease of tail-flick latencies to the thermoalgesic stimulus, without significant changes of the stress analgesia induced by the restraint stress. In the pretreated animals with L-NAME a progressive increase of latency time was obtained and the increased latencies induced by acute immobilization appeared significantly potentiated. These results offer new indirect evidence in favour of the modulatory role of NO in the thermoalgesic sensitivity and stress induced analgesia.

Analgesia↗