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Biomedical subjects

V Dornetzhuber

Publications and source records attributed to V Dornetzhuber.

At least 19 recordsLinked to original sources
PubMed1982

Pulmonary mycobacteriosis caused by Mycobacterium xenopi. Report of a case.

M. xenopi was definitely demonstrated 14 times in the sputum of a 70-year-old man with chronic obstructive lung disease. Sputum conversion was achieved by combined chemotherapy, but the patient died of cor pulmonale and associated terminal pneumonia. Autopsy revealed moderately advanced old fibrotic pulmonary lesions of tuberculous origin including a large "open healed" cavity, and recent involvement of lymphatic nodules with a bronchonodular fistula accompanied by dispersed lesions in the surrounding pulmonary tissue. Culture of the latter lesions yielded M. xenopi and were formed by central necrosis with numerous acid-fast rods surrounded by a hyaline capsule without any specific or nonspecific inflammation. No histological differences were detected between these lesions and lesions from a disease provoked by M. tuberculosis.

Aged↗
PubMed1980

Application of gibberelic acid (GA) alone or together wih cytostatics in treatment of lung cancer.

Gibberelic acid (GA) was used alone or in combination with cytostatics (Vincristine, Cyclophosphamide, HN3), surgical treatment or radiotherapy, in treatment of 65 patients with lung cancer. The patinets were followed up from the end of 1972 until the end of 1977. It was found that the administration of GA, at the given doses, did not cause toxic effects in treated patients and it improved for shorter or longer period of time some metabolic functions and activity of hemopoiesis. Some analgetic effect(2) of GA was also registered.

Adult↗
PubMed1980

[The in vivo influence of gibberellic acid (GA3) on the phagocytic properties of peritoneal macrophages (author's transl)].

Different concentrations of gibberellin acid GA3 - 10.0 mg, 1.0 mg and 0.1 mg - were applied intraperitoneally to white mice of the SPF strain on four consecutive days. Following the last application we injected E. coli, P. aerug. and Pr. vulg. intraperitoneally into the peritoneum of these animals, in a quantity of 1.5-2.0 X 10(6)/0.5 ml of sterile phosphate buffer. The peritoneal macrophages obtained by puncturing the peritoneum of the animals killed under chloroform anaesthesia showed, as compared with those of the control animals statistically most significantly higher values (P < 0.001) of the phagocytic factor and phagocytic index as well as of the activity of the acid phosphatase. In the test animals which received gibberellin acid, the inhibition of the lysosomal activity of peritoneal macrophages as a result of the application of trypan blue did not reach the level which was found to exist in the control animals and those infected with B CG - Praha.

Animals↗
PubMed1975

[Sensitivity of m. kansasii strains to various antibiotics and chemotherapeutics in vitro and in vivo (author's transl)].

Sensitivity of 40 strains of M. kansasii (var. luciflava) to various antibiotics and chemotherapeutics in vitro and in vivo was examined. The strains showed considerable individual variability in their susceptibility in vitro, most were more resistant to isoniazid and PAS and about one half of the investigated strains to streptomycin, too, if correlated to "wild" strains of M. tuberculosis. Susceptibility to ethionamide, thiosemicarbazone (Conteben), viomycin, kanamycin and cycloserine appears to be the same as in the case of M. tuberculosis strains, but the resistance to pyrazinamide is higher. Good effect has been observed in vitro with rifampicin, ethambutol, capreomycin and phenazine derivative B 663. Oleandomycin and gentamycin are ineffectual in the dosages of drugs we used. The activity of most of these drugs was observed in experimental infections of white mice--in mono-therapy and in various combinations-provoked by different strains of M. kansasii. The main criterion of the effectivity of the treatment was the enumeration of viable mycobacterial units in the lungs of the mice in ten-days intervals; in one part of the experiments the histological examination of the various organs of the mice was performed. The drugs of the I. and II. line of antituberculotics were ineffective or showed only a slight effect. A very good effect of rifampicin, ethambutol and phenazine derivative B 663 in monotherapy and in multiply drug therapy was observed.

Animals↗