Content of serum immunoglobulins (Ig) was estimated in patients with various types of hemoblastoses by radial immunodiffusion. Reactive alterations in content of Ig were observed in several patients with acute leukosis and chronic myeloleukosis. In patients with chronic lympholeukosis the decrease in concentration of serum Ig was manifested as a syndrom of the antibodies insufficiency. Monoclonic type of IgM or the reactive increase in Ig content was found only in several cases of chronic lympholeukosis. Lymphogranulomatosis and other malignant lymphomas were inhirent in the distinct increase of Ig and primarily of IgG. Content of normal Ig was distinctly decreased and monoclonic Ig (paraprotein) was found in paraproteinemic hemoblastoses. The observed alterations in the Ig content under hemoblastoses are of diagnostic and prognostic importance.

Acute Disease↗

PubMedDate not supplied

[Effect of a fat emulsion on cellular immunity in experimental parenteral feeding].

The experiments on guinea pigs and male CBA mice have shown that short-term daily administration of lipidin-2 (3 infusions) in a dose of 2 g/kg induces a decrease in T-lymphocyte proliferative activity. Increased multiplicity of the agent infusions up to 7 and 14 is attended by reversible quantitative and functional changes in the T-lymphocyte population and D-cells.

Animals↗

PubMedDate not supplied

[Immunoelectrophoretic characterization of the changes in serum proteins in hemoblastosis].

Immunoelectrophoretic study of serum proteins in patients with various types of malignant proliferations of haemopoietic tissue was performed. It was established that myeloproliferative diseases (chronic myeloleukemia, acute leukemia) are notable for changes in alpha 2-globulins (frequent increase in the content of alpha 2-macroglobulin, haptoglobin) increase in the of beta 1 A-globulin as well as for reactive increase in the content of one or several immunoglobulins. During malignant proliferations of lymphoreticular tissue (chronic lympholeukemia, lymphosarcoma, myeloma, lymphogranulomatosis), major disturbances occur in the group of immunoglobulins, changes in which during this pathology can be of three types: reactive increase, decrease with a syndrome of antibody deficiency, paraproteinemia. The type of changes of immunoglobulins is determined by morphogenetic species of malignant cells.

Blood Proteins↗

PubMedDate not supplied

[The immune status of patients with acute and chronic epididymitis].

The trial entered 49 patients with epididymitis and 18 age-matched control subjects without this disease. The patients were divided into 3 groups: 21 patients of group 1 were treated surgically (epididymotomy with drainage of the scrotal cavity), 15 patients of group 2 were inoperable, 13 patients of group 3 suffered from exacerbation of chronic epididymitis. Before treatment the patients were examined clinically, bacteriologically and immunologically. Measured were: main populations and subpopulations of lymphocytes using indirect immunofluorescence and monoclonal antibodies; concentration of serum immunoglobulins using radial immunodiffusion; overall content of circulating immune complexes precipitating by polyetilene glycol-6000; phagocytosing neutrophil function by absorption of latex particles. The immunogram of epididymitis patients was indicative of the inflammation stage and activity which is important for choice of treatment. Immunogram of group 1 patients was characteristic of the peak of acute inflammation, of group 2 was typical for attenuation of acute inflammation. Immunogram of group 3 patients corresponded to exacerbation of chronic inflammation and secondary immunodeficiency.

Acute Disease↗